Acidic pH modulation of Na+ channels in trigeminal mesencephalic nucleus neurons

In Sik Kang, Jin Hwa Cho, In Sun Choi, Do Yeon Kim, Il Sung Jang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Cell bodies of trigeminal mesencephalic nucleus (Vmes) neurons are located within the central nervous system, and therefore, peripheral as well as central acidosis can modulate the excitability of Vmes neurons. Here, we report the effect of acidic pH on voltage-gated Na+ channels in acutely isolated rat Vmes neurons using a conventional whole-cell patch clamp technique. Acidic pH (pH 6.0) slightly but significantly shifted both the activation and steady-state fast inactivation relationships toward depolarized potentials. However, acidic pH (pH 6.0) had a minor effect on the inactivation kinetics of voltage-gated Na+ channels. Less sensitivity of voltage-gated Na+ channels to acidic pH may allow Vmes neurons to transduce the precise proprioceptive information even under acidic pH conditions.

Original languageEnglish
Pages (from-to)1274-1280
Number of pages7
JournalNeuroReport
Volume27
Issue number17
DOIs
StatePublished - 1 Dec 2016

Keywords

  • acidosis
  • patch clamp
  • proprioception
  • trigeminal mesencephalic nucleus
  • voltage-gated Na channels

Fingerprint

Dive into the research topics of 'Acidic pH modulation of Na+ channels in trigeminal mesencephalic nucleus neurons'. Together they form a unique fingerprint.

Cite this