Action of Rubus coreanus extract on systemic and local anaphylaxis

Tae Yong Shin; Sang Hyun Kim; Eun Soon Lee; Dong Ok Eom; Hyung Min Kim

doi:10.1002/ptr.925

Action of Rubus coreanus extract on systemic and local anaphylaxis

Tae Yong Shin, Sang Hyun Kim, Eun Soon Lee, Dong Ok Eom, Hyung Min Kim

Department of Medicine

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The effect was investigated of the aqueous extract of Rubus coreanus Miq. (Rosaceae) fruits (RCAE) on systemic and local anaphylaxis. RCAE (0.01-1 g/kg) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. RCAE (1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. Pretreatment with RCAE at the same concentration before systemic anaphylaxis reduced the plasma histamine levels in a dose-dependent manner. RCAE (0.001-1 mg/mL) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cAMP in RPMC, when RCAE was added, significantly increased, compared with that of the normal control. Moreover, RCAE(0.01-1 mg/mL) had a significant inhibitory effect on anti-DNP IgE-induced tumour necrosis factor-a production from RPMC. These results indicate that RCAE may possess antianaphylactic action.

Original language	English
Pages (from-to)	508-513
Number of pages	6
Journal	Phytotherapy Research
Volume	16
Issue number	6
DOIs	https://doi.org/10.1002/ptr.925
State	Published - Sep 2002

Keywords

Anaphylaxis
Anti-DNP IgE
CAMP
Compound 48/80
Rubus coreanus
Tumour necrosis factor-α

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title = "Action of Rubus coreanus extract on systemic and local anaphylaxis",

abstract = "The effect was investigated of the aqueous extract of Rubus coreanus Miq. (Rosaceae) fruits (RCAE) on systemic and local anaphylaxis. RCAE (0.01-1 g/kg) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. RCAE (1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. Pretreatment with RCAE at the same concentration before systemic anaphylaxis reduced the plasma histamine levels in a dose-dependent manner. RCAE (0.001-1 mg/mL) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cAMP in RPMC, when RCAE was added, significantly increased, compared with that of the normal control. Moreover, RCAE(0.01-1 mg/mL) had a significant inhibitory effect on anti-DNP IgE-induced tumour necrosis factor-a production from RPMC. These results indicate that RCAE may possess antianaphylactic action.",

keywords = "Anaphylaxis, Anti-DNP IgE, CAMP, Compound 48/80, Rubus coreanus, Tumour necrosis factor-α",

author = "Shin, {Tae Yong} and Kim, {Sang Hyun} and Lee, {Eun Soon} and Eom, {Dong Ok} and Kim, {Hyung Min}",

year = "2002",

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AU - Shin, Tae Yong

AU - Kim, Sang Hyun

AU - Lee, Eun Soon

AU - Eom, Dong Ok

AU - Kim, Hyung Min

PY - 2002/9

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N2 - The effect was investigated of the aqueous extract of Rubus coreanus Miq. (Rosaceae) fruits (RCAE) on systemic and local anaphylaxis. RCAE (0.01-1 g/kg) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. RCAE (1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. Pretreatment with RCAE at the same concentration before systemic anaphylaxis reduced the plasma histamine levels in a dose-dependent manner. RCAE (0.001-1 mg/mL) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cAMP in RPMC, when RCAE was added, significantly increased, compared with that of the normal control. Moreover, RCAE(0.01-1 mg/mL) had a significant inhibitory effect on anti-DNP IgE-induced tumour necrosis factor-a production from RPMC. These results indicate that RCAE may possess antianaphylactic action.

AB - The effect was investigated of the aqueous extract of Rubus coreanus Miq. (Rosaceae) fruits (RCAE) on systemic and local anaphylaxis. RCAE (0.01-1 g/kg) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. RCAE (1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. Pretreatment with RCAE at the same concentration before systemic anaphylaxis reduced the plasma histamine levels in a dose-dependent manner. RCAE (0.001-1 mg/mL) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cAMP in RPMC, when RCAE was added, significantly increased, compared with that of the normal control. Moreover, RCAE(0.01-1 mg/mL) had a significant inhibitory effect on anti-DNP IgE-induced tumour necrosis factor-a production from RPMC. These results indicate that RCAE may possess antianaphylactic action.

KW - Anaphylaxis

KW - Anti-DNP IgE

KW - CAMP

KW - Compound 48/80

KW - Rubus coreanus

KW - Tumour necrosis factor-α

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Action of Rubus coreanus extract on systemic and local anaphylaxis

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