Age is a determinant factor in the susceptibility of domestic ducks to H5 clade 2.3.2.1c and 2.3.4.4e high pathogenicity avian influenza viruses

Sun Hak Lee, Jiho Lee, Jin Yong Noh, Jei Hyun Jeong, Jun Beom Kim, Jung Hoon Kwon, Sungsu Youk, Chang Seon Song, Dong Hun Lee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

High pathogenicity avian influenza (HPAI) is a viral disease with devastating consequences for the poultry industry worldwide. Domestic ducks are a major source of HPAI viruses in many Eurasian countries. The infectivity and pathogenicity of HPAI viruses in ducks vary depending on host and viral factors. To assess the factors influencing the infectivity and pathogenicity of HPAI viruses in ducks, we compared the pathobiology of two HPAI viruses (H5N1 clade 2.3.2.1c and H5N6 clade 2.3.4.4e) in 5- and 25-week-old ducks. Both HPAI viruses caused mortality in a dose-dependent manner (104, 106, and 108 EID50) in young ducks. By contrast, adult ducks were infected but exhibited no mortality due to either virus. Viral excretion was higher in young ducks than in adults, regardless of the HPAI strain. These findings demonstrate the age-dependent mortality of clade 2.3.2.1c and clade 2.3.4.4e H5 HPAI viruses in ducks.

Original languageEnglish
Article number1207289
JournalFrontiers in Veterinary Science
Volume10
DOIs
StatePublished - 2023

Keywords

  • age-related pathogenicity
  • clade 2.3.2.1c H5N1
  • clade 2.3.4.4e H5N6
  • duck
  • high pathogenicity avian influenza

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