Age-related changes of γ-aminobutyric acid transaminase immunoreactivity in the hippocampus and dentate gyrus of the Mongolian gerbil

Koo Hwang In; Won Kim Dae; Ki Yeon Yoo; Soo Kim Duk; Kil Soo Kim; Hoon Kang Jung; Young Choi Soo; Yong Sun Kim; Tae Cheon Kang; Ho Won Moo

doi:10.1016/j.brainres.2004.05.022

Age-related changes of γ-aminobutyric acid transaminase immunoreactivity in the hippocampus and dentate gyrus of the Mongolian gerbil

Koo Hwang In, Won Kim Dae, Ki Yeon Yoo, Soo Kim Duk, Kil Soo Kim, Hoon Kang Jung, Young Choi Soo, Yong Sun Kim, Tae Cheon Kang, Ho Won Moo

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We investigated the age-related changes of γ-aminobutyric acid transaminase (GABA-T, a GABA degradation enzyme) in the hippocampus and dentate gyrus of the gerbil at postnatal month 1 (PM 1), PM 3, PM 6, PM 12, and PM 24. Age-related changes of GABA-T immunoreactivity were distinct in the hippocampal CA1 region and in the dentate gyrus. GABA-T immunoreactivity was weak at PM 1, but at PM 3, it had increased significantly, and then increased further. Between PM 6 and PM 12, strong GABA-T immunoreactivity was found in nonpyramidal cells (GABAergic) in the stratum pyramidale of the CA1 region, and at PM 6, strong GABA-T immunoreactivity was found in neurons of the dentate gyrus subgranular zone. At PM 24, CA1 pyramidal cells showed strong GABA-T immunoreactivity. Western blot analysis showed a pattern of GABA-T expression similar to that shown by immunohistochemistry at various ages. In conclusion, our results suggest that the age-related changes of GABA-T provide important information about the aged brain with GABA dysfunction.

Original language	English
Pages (from-to)	77-84
Number of pages	8
Journal	Brain Research
Volume	1017
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2004.05.022
State	Published - 13 Aug 2004

Keywords

Aging
Dentate gyrus
Disorders of the nervous system
GABA
GABA transaminase
Gerbil
Hippocampus
Neurodegeneration

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10.1016/j.brainres.2004.05.022

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title = "Age-related changes of γ-aminobutyric acid transaminase immunoreactivity in the hippocampus and dentate gyrus of the Mongolian gerbil",

abstract = "We investigated the age-related changes of γ-aminobutyric acid transaminase (GABA-T, a GABA degradation enzyme) in the hippocampus and dentate gyrus of the gerbil at postnatal month 1 (PM 1), PM 3, PM 6, PM 12, and PM 24. Age-related changes of GABA-T immunoreactivity were distinct in the hippocampal CA1 region and in the dentate gyrus. GABA-T immunoreactivity was weak at PM 1, but at PM 3, it had increased significantly, and then increased further. Between PM 6 and PM 12, strong GABA-T immunoreactivity was found in nonpyramidal cells (GABAergic) in the stratum pyramidale of the CA1 region, and at PM 6, strong GABA-T immunoreactivity was found in neurons of the dentate gyrus subgranular zone. At PM 24, CA1 pyramidal cells showed strong GABA-T immunoreactivity. Western blot analysis showed a pattern of GABA-T expression similar to that shown by immunohistochemistry at various ages. In conclusion, our results suggest that the age-related changes of GABA-T provide important information about the aged brain with GABA dysfunction.",

keywords = "Aging, Dentate gyrus, Disorders of the nervous system, GABA, GABA transaminase, Gerbil, Hippocampus, Neurodegeneration",

author = "In, {Koo Hwang} and Dae, {Won Kim} and Yoo, {Ki Yeon} and Duk, {Soo Kim} and Kim, {Kil Soo} and Jung, {Hoon Kang} and Soo, {Young Choi} and Kim, {Yong Sun} and Kang, {Tae Cheon} and Moo, {Ho Won}",

year = "2004",

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doi = "10.1016/j.brainres.2004.05.022",

language = "English",

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pages = "77--84",

journal = "Brain Research",

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T1 - Age-related changes of γ-aminobutyric acid transaminase immunoreactivity in the hippocampus and dentate gyrus of the Mongolian gerbil

AU - In, Koo Hwang

AU - Dae, Won Kim

AU - Yoo, Ki Yeon

AU - Duk, Soo Kim

AU - Kim, Kil Soo

AU - Jung, Hoon Kang

AU - Soo, Young Choi

AU - Kim, Yong Sun

AU - Kang, Tae Cheon

AU - Moo, Ho Won

PY - 2004/8/13

Y1 - 2004/8/13

N2 - We investigated the age-related changes of γ-aminobutyric acid transaminase (GABA-T, a GABA degradation enzyme) in the hippocampus and dentate gyrus of the gerbil at postnatal month 1 (PM 1), PM 3, PM 6, PM 12, and PM 24. Age-related changes of GABA-T immunoreactivity were distinct in the hippocampal CA1 region and in the dentate gyrus. GABA-T immunoreactivity was weak at PM 1, but at PM 3, it had increased significantly, and then increased further. Between PM 6 and PM 12, strong GABA-T immunoreactivity was found in nonpyramidal cells (GABAergic) in the stratum pyramidale of the CA1 region, and at PM 6, strong GABA-T immunoreactivity was found in neurons of the dentate gyrus subgranular zone. At PM 24, CA1 pyramidal cells showed strong GABA-T immunoreactivity. Western blot analysis showed a pattern of GABA-T expression similar to that shown by immunohistochemistry at various ages. In conclusion, our results suggest that the age-related changes of GABA-T provide important information about the aged brain with GABA dysfunction.

AB - We investigated the age-related changes of γ-aminobutyric acid transaminase (GABA-T, a GABA degradation enzyme) in the hippocampus and dentate gyrus of the gerbil at postnatal month 1 (PM 1), PM 3, PM 6, PM 12, and PM 24. Age-related changes of GABA-T immunoreactivity were distinct in the hippocampal CA1 region and in the dentate gyrus. GABA-T immunoreactivity was weak at PM 1, but at PM 3, it had increased significantly, and then increased further. Between PM 6 and PM 12, strong GABA-T immunoreactivity was found in nonpyramidal cells (GABAergic) in the stratum pyramidale of the CA1 region, and at PM 6, strong GABA-T immunoreactivity was found in neurons of the dentate gyrus subgranular zone. At PM 24, CA1 pyramidal cells showed strong GABA-T immunoreactivity. Western blot analysis showed a pattern of GABA-T expression similar to that shown by immunohistochemistry at various ages. In conclusion, our results suggest that the age-related changes of GABA-T provide important information about the aged brain with GABA dysfunction.

KW - Aging

KW - Dentate gyrus

KW - Disorders of the nervous system

KW - GABA

KW - GABA transaminase

KW - Gerbil

KW - Hippocampus

KW - Neurodegeneration

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JO - Brain Research

JF - Brain Research

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ER -

Age-related changes of γ-aminobutyric acid transaminase immunoreactivity in the hippocampus and dentate gyrus of the Mongolian gerbil

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