Age-related changes of γ-aminobutyric acid transaminase immunoreactivity in the hippocampus and dentate gyrus of the Mongolian gerbil

Koo Hwang In; Won Kim Dae; Ki Yeon Yoo; Soo Kim Duk; Kil Soo Kim; Hoon Kang Jung; Young Choi Soo; Yong Sun Kim; Tae Cheon Kang; Ho Won Moo

doi:10.1016/j.brainres.2004.05.022

Age-related changes of γ-aminobutyric acid transaminase immunoreactivity in the hippocampus and dentate gyrus of the Mongolian gerbil

Koo Hwang In
, Won Kim Dae
, Ki Yeon Yoo
, Soo Kim Duk
, Kil Soo Kim
, Hoon Kang Jung
, Young Choi Soo
, Yong Sun Kim
, Tae Cheon Kang
, Ho Won Moo

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We investigated the age-related changes of γ-aminobutyric acid transaminase (GABA-T, a GABA degradation enzyme) in the hippocampus and dentate gyrus of the gerbil at postnatal month 1 (PM 1), PM 3, PM 6, PM 12, and PM 24. Age-related changes of GABA-T immunoreactivity were distinct in the hippocampal CA1 region and in the dentate gyrus. GABA-T immunoreactivity was weak at PM 1, but at PM 3, it had increased significantly, and then increased further. Between PM 6 and PM 12, strong GABA-T immunoreactivity was found in nonpyramidal cells (GABAergic) in the stratum pyramidale of the CA1 region, and at PM 6, strong GABA-T immunoreactivity was found in neurons of the dentate gyrus subgranular zone. At PM 24, CA1 pyramidal cells showed strong GABA-T immunoreactivity. Western blot analysis showed a pattern of GABA-T expression similar to that shown by immunohistochemistry at various ages. In conclusion, our results suggest that the age-related changes of GABA-T provide important information about the aged brain with GABA dysfunction.

Original language	English
Pages (from-to)	77-84
Number of pages	8
Journal	Brain Research
Volume	1017
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2004.05.022
State	Published - 13 Aug 2004

Keywords

Aging
Dentate gyrus
Disorders of the nervous system
GABA
GABA transaminase
Gerbil
Hippocampus
Neurodegeneration

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10.1016/j.brainres.2004.05.022

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title = "Age-related changes of γ-aminobutyric acid transaminase immunoreactivity in the hippocampus and dentate gyrus of the Mongolian gerbil",

abstract = "We investigated the age-related changes of γ-aminobutyric acid transaminase (GABA-T, a GABA degradation enzyme) in the hippocampus and dentate gyrus of the gerbil at postnatal month 1 (PM 1), PM 3, PM 6, PM 12, and PM 24. Age-related changes of GABA-T immunoreactivity were distinct in the hippocampal CA1 region and in the dentate gyrus. GABA-T immunoreactivity was weak at PM 1, but at PM 3, it had increased significantly, and then increased further. Between PM 6 and PM 12, strong GABA-T immunoreactivity was found in nonpyramidal cells (GABAergic) in the stratum pyramidale of the CA1 region, and at PM 6, strong GABA-T immunoreactivity was found in neurons of the dentate gyrus subgranular zone. At PM 24, CA1 pyramidal cells showed strong GABA-T immunoreactivity. Western blot analysis showed a pattern of GABA-T expression similar to that shown by immunohistochemistry at various ages. In conclusion, our results suggest that the age-related changes of GABA-T provide important information about the aged brain with GABA dysfunction.",

keywords = "Aging, Dentate gyrus, Disorders of the nervous system, GABA, GABA transaminase, Gerbil, Hippocampus, Neurodegeneration",

author = "In, \{Koo Hwang\} and Dae, \{Won Kim\} and Yoo, \{Ki Yeon\} and Duk, \{Soo Kim\} and Kim, \{Kil Soo\} and Jung, \{Hoon Kang\} and Soo, \{Young Choi\} and Kim, \{Yong Sun\} and Kang, \{Tae Cheon\} and Moo, \{Ho Won\}",

year = "2004",

month = aug,

day = "13",

doi = "10.1016/j.brainres.2004.05.022",

language = "English",

volume = "1017",

pages = "77--84",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Age-related changes of γ-aminobutyric acid transaminase immunoreactivity in the hippocampus and dentate gyrus of the Mongolian gerbil

AU - In, Koo Hwang

AU - Dae, Won Kim

AU - Yoo, Ki Yeon

AU - Duk, Soo Kim

AU - Kim, Kil Soo

AU - Jung, Hoon Kang

AU - Soo, Young Choi

AU - Kim, Yong Sun

AU - Kang, Tae Cheon

AU - Moo, Ho Won

PY - 2004/8/13

Y1 - 2004/8/13

N2 - We investigated the age-related changes of γ-aminobutyric acid transaminase (GABA-T, a GABA degradation enzyme) in the hippocampus and dentate gyrus of the gerbil at postnatal month 1 (PM 1), PM 3, PM 6, PM 12, and PM 24. Age-related changes of GABA-T immunoreactivity were distinct in the hippocampal CA1 region and in the dentate gyrus. GABA-T immunoreactivity was weak at PM 1, but at PM 3, it had increased significantly, and then increased further. Between PM 6 and PM 12, strong GABA-T immunoreactivity was found in nonpyramidal cells (GABAergic) in the stratum pyramidale of the CA1 region, and at PM 6, strong GABA-T immunoreactivity was found in neurons of the dentate gyrus subgranular zone. At PM 24, CA1 pyramidal cells showed strong GABA-T immunoreactivity. Western blot analysis showed a pattern of GABA-T expression similar to that shown by immunohistochemistry at various ages. In conclusion, our results suggest that the age-related changes of GABA-T provide important information about the aged brain with GABA dysfunction.

AB - We investigated the age-related changes of γ-aminobutyric acid transaminase (GABA-T, a GABA degradation enzyme) in the hippocampus and dentate gyrus of the gerbil at postnatal month 1 (PM 1), PM 3, PM 6, PM 12, and PM 24. Age-related changes of GABA-T immunoreactivity were distinct in the hippocampal CA1 region and in the dentate gyrus. GABA-T immunoreactivity was weak at PM 1, but at PM 3, it had increased significantly, and then increased further. Between PM 6 and PM 12, strong GABA-T immunoreactivity was found in nonpyramidal cells (GABAergic) in the stratum pyramidale of the CA1 region, and at PM 6, strong GABA-T immunoreactivity was found in neurons of the dentate gyrus subgranular zone. At PM 24, CA1 pyramidal cells showed strong GABA-T immunoreactivity. Western blot analysis showed a pattern of GABA-T expression similar to that shown by immunohistochemistry at various ages. In conclusion, our results suggest that the age-related changes of GABA-T provide important information about the aged brain with GABA dysfunction.

KW - Aging

KW - Dentate gyrus

KW - Disorders of the nervous system

KW - GABA

KW - GABA transaminase

KW - Gerbil

KW - Hippocampus

KW - Neurodegeneration

UR - https://www.scopus.com/pages/publications/3142686652

U2 - 10.1016/j.brainres.2004.05.022

DO - 10.1016/j.brainres.2004.05.022

M3 - Article

C2 - 15261102

AN - SCOPUS:3142686652

SN - 0006-8993

VL - 1017

SP - 77

EP - 84

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Age-related changes of γ-aminobutyric acid transaminase immunoreactivity in the hippocampus and dentate gyrus of the Mongolian gerbil

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