Alterations in pulmonary vasomotor modulators post aerobic exercise training in non-alcoholic fatty liver disease

Jinkyung Cho; Bruce D. Johnson; Kymberly D. Watt; Alexander S. Niven; Junchul Shin; Chul Ho Kim

doi:10.1016/j.resp.2023.104089

Alterations in pulmonary vasomotor modulators post aerobic exercise training in non-alcoholic fatty liver disease

Jinkyung Cho, Bruce D. Johnson, Kymberly D. Watt, Alexander S. Niven, Junchul Shin, Chul Ho Kim

Department of Kinesiology

Mayo Clinic Rochester, MN

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated the impact of exercise training on major pulmonary vasomotor mediators and receptors including endothelial nitric oxide synthase (eNOS) inducible NOS (iNOS), endothelin-1 (ET-1), ET-1 receptors A (ET_A) and-B (ET_B) in high-fat-high-carbohydrate (HFHC) induced non-alcoholic fatty liver disease (NAFLD). NAFLD increased iNOS, ET-1 and ET_A (p < 0.05)_, but not ET_B (p > 0.05). Exercise attenuated iNOS, ET-1 and ET_A (p < 0.05)_., but not ET_B (p > 0.05) and eNOS (p > 0.05). Exercise training is beneficial for pulmonary vasculature in NAFLD.

Original language	English
Article number	104089
Journal	Respiratory Physiology and Neurobiology
Volume	314
DOIs	https://doi.org/10.1016/j.resp.2023.104089
State	Published - Aug 2023

Keywords

ENOS
ET-1
Exercise
INOS
NAFLD
Pulmonary

Access to Document

10.1016/j.resp.2023.104089

Cite this

@article{b0a9dab4a531482ca06d2bfa4c2c8c60,

title = "Alterations in pulmonary vasomotor modulators post aerobic exercise training in non-alcoholic fatty liver disease",

abstract = "This study investigated the impact of exercise training on major pulmonary vasomotor mediators and receptors including endothelial nitric oxide synthase (eNOS) inducible NOS (iNOS), endothelin-1 (ET-1), ET-1 receptors A (ETA) and-B (ETB) in high-fat-high-carbohydrate (HFHC) induced non-alcoholic fatty liver disease (NAFLD). NAFLD increased iNOS, ET-1 and ETA (p < 0.05), but not ETB (p > 0.05). Exercise attenuated iNOS, ET-1 and ETA (p < 0.05)., but not ETB (p > 0.05) and eNOS (p > 0.05). Exercise training is beneficial for pulmonary vasculature in NAFLD.",

keywords = "ENOS, ET-1, Exercise, INOS, NAFLD, Pulmonary",

author = "Jinkyung Cho and Johnson, {Bruce D.} and Watt, {Kymberly D.} and Niven, {Alexander S.} and Junchul Shin and Kim, {Chul Ho}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = aug,

doi = "10.1016/j.resp.2023.104089",

language = "English",

volume = "314",

journal = "Respiratory Physiology and Neurobiology",

issn = "1569-9048",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Alterations in pulmonary vasomotor modulators post aerobic exercise training in non-alcoholic fatty liver disease

AU - Cho, Jinkyung

AU - Johnson, Bruce D.

AU - Watt, Kymberly D.

AU - Niven, Alexander S.

AU - Shin, Junchul

AU - Kim, Chul Ho

PY - 2023/8

Y1 - 2023/8

N2 - This study investigated the impact of exercise training on major pulmonary vasomotor mediators and receptors including endothelial nitric oxide synthase (eNOS) inducible NOS (iNOS), endothelin-1 (ET-1), ET-1 receptors A (ETA) and-B (ETB) in high-fat-high-carbohydrate (HFHC) induced non-alcoholic fatty liver disease (NAFLD). NAFLD increased iNOS, ET-1 and ETA (p < 0.05), but not ETB (p > 0.05). Exercise attenuated iNOS, ET-1 and ETA (p < 0.05)., but not ETB (p > 0.05) and eNOS (p > 0.05). Exercise training is beneficial for pulmonary vasculature in NAFLD.

AB - This study investigated the impact of exercise training on major pulmonary vasomotor mediators and receptors including endothelial nitric oxide synthase (eNOS) inducible NOS (iNOS), endothelin-1 (ET-1), ET-1 receptors A (ETA) and-B (ETB) in high-fat-high-carbohydrate (HFHC) induced non-alcoholic fatty liver disease (NAFLD). NAFLD increased iNOS, ET-1 and ETA (p < 0.05), but not ETB (p > 0.05). Exercise attenuated iNOS, ET-1 and ETA (p < 0.05)., but not ETB (p > 0.05) and eNOS (p > 0.05). Exercise training is beneficial for pulmonary vasculature in NAFLD.

KW - ENOS

KW - ET-1

KW - Exercise

KW - INOS

KW - NAFLD

KW - Pulmonary

UR - http://www.scopus.com/inward/record.url?scp=85161090121&partnerID=8YFLogxK

U2 - 10.1016/j.resp.2023.104089

DO - 10.1016/j.resp.2023.104089

M3 - Article

C2 - 37269888

AN - SCOPUS:85161090121

SN - 1569-9048

VL - 314

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

M1 - 104089

ER -

Alterations in pulmonary vasomotor modulators post aerobic exercise training in non-alcoholic fatty liver disease

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this