Altered GABAB receptor immunoreactivity in the gerbil hippocampus induced by baclofen and phaclofen, not seizure activity

Seung Kook Park; Sung Jin An; In Koo Hwang; Dae Won Kim; Ju Young Jung; Moo Ho Won; Soo Young Choi; Oh Shin Kwon; Young Gil Jeong; Tae Cheon Kang

doi:10.1016/j.neures.2004.05.004

Altered GABA_B receptor immunoreactivity in the gerbil hippocampus induced by baclofen and phaclofen, not seizure activity

Seung Kook Park, Sung Jin An, In Koo Hwang, Dae Won Kim, Ju Young Jung, Moo Ho Won, Soo Young Choi, Oh Shin Kwon, Young Gil Jeong, Tae Cheon Kang

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The present study was performed to determine whether the effects induced by GABA_B receptor-acting drugs would be related with the alteration in GABA_B receptor expression in the hippocampus using Mongolian gerbil, a genetic epilepsy model. The distribution patterns of both GABA_B receptor 1A/B and GABA_Breceptor 2 immunoreactivities were similarly detected in the hippocampi of normal and seizure-prone gerbils. Following baclofen (GABA_B receptor agonist) or phaclofen (GABA_B receptor antagonist) treatment, GABA_B receptor immunoreactivities were decreased or increased by dose-dependent manners, respectively. Vigabatrin (GABA transaminase inhibitor) or 3-mercaptopropionic acid (GAD inhibitor) treatment did not affect GABA_B receptor expressions. These findings suggest that GABA_B receptor expression in the gerbil hippocampus may be altered by baclofen or phaclofen treatment.

Original language	English
Pages (from-to)	405-416
Number of pages	12
Journal	Neuroscience Research
Volume	49
Issue number	4
DOIs	https://doi.org/10.1016/j.neures.2004.05.004
State	Published - Aug 2004

Keywords

3-MPA
Baclofen
Epilepsy
GABA receptor
Gerbil
Hippocampus
Phaclofen
Seizure
Vigabatrin

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10.1016/j.neures.2004.05.004

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title = "Altered GABAB receptor immunoreactivity in the gerbil hippocampus induced by baclofen and phaclofen, not seizure activity",

abstract = "The present study was performed to determine whether the effects induced by GABAB receptor-acting drugs would be related with the alteration in GABAB receptor expression in the hippocampus using Mongolian gerbil, a genetic epilepsy model. The distribution patterns of both GABAB receptor 1A/B and GABABreceptor 2 immunoreactivities were similarly detected in the hippocampi of normal and seizure-prone gerbils. Following baclofen (GABAB receptor agonist) or phaclofen (GABAB receptor antagonist) treatment, GABAB receptor immunoreactivities were decreased or increased by dose-dependent manners, respectively. Vigabatrin (GABA transaminase inhibitor) or 3-mercaptopropionic acid (GAD inhibitor) treatment did not affect GABAB receptor expressions. These findings suggest that GABAB receptor expression in the gerbil hippocampus may be altered by baclofen or phaclofen treatment.",

keywords = "3-MPA, Baclofen, Epilepsy, GABA receptor, Gerbil, Hippocampus, Phaclofen, Seizure, Vigabatrin",

author = "Park, {Seung Kook} and An, {Sung Jin} and Hwang, {In Koo} and Kim, {Dae Won} and Jung, {Ju Young} and Won, {Moo Ho} and Choi, {Soo Young} and Kwon, {Oh Shin} and Jeong, {Young Gil} and Kang, {Tae Cheon}",

year = "2004",

month = aug,

doi = "10.1016/j.neures.2004.05.004",

language = "English",

volume = "49",

pages = "405--416",

journal = "Neuroscience Research",

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T1 - Altered GABAB receptor immunoreactivity in the gerbil hippocampus induced by baclofen and phaclofen, not seizure activity

AU - Park, Seung Kook

AU - An, Sung Jin

AU - Hwang, In Koo

AU - Kim, Dae Won

AU - Jung, Ju Young

AU - Won, Moo Ho

AU - Choi, Soo Young

AU - Kwon, Oh Shin

AU - Jeong, Young Gil

AU - Kang, Tae Cheon

PY - 2004/8

Y1 - 2004/8

N2 - The present study was performed to determine whether the effects induced by GABAB receptor-acting drugs would be related with the alteration in GABAB receptor expression in the hippocampus using Mongolian gerbil, a genetic epilepsy model. The distribution patterns of both GABAB receptor 1A/B and GABABreceptor 2 immunoreactivities were similarly detected in the hippocampi of normal and seizure-prone gerbils. Following baclofen (GABAB receptor agonist) or phaclofen (GABAB receptor antagonist) treatment, GABAB receptor immunoreactivities were decreased or increased by dose-dependent manners, respectively. Vigabatrin (GABA transaminase inhibitor) or 3-mercaptopropionic acid (GAD inhibitor) treatment did not affect GABAB receptor expressions. These findings suggest that GABAB receptor expression in the gerbil hippocampus may be altered by baclofen or phaclofen treatment.

AB - The present study was performed to determine whether the effects induced by GABAB receptor-acting drugs would be related with the alteration in GABAB receptor expression in the hippocampus using Mongolian gerbil, a genetic epilepsy model. The distribution patterns of both GABAB receptor 1A/B and GABABreceptor 2 immunoreactivities were similarly detected in the hippocampi of normal and seizure-prone gerbils. Following baclofen (GABAB receptor agonist) or phaclofen (GABAB receptor antagonist) treatment, GABAB receptor immunoreactivities were decreased or increased by dose-dependent manners, respectively. Vigabatrin (GABA transaminase inhibitor) or 3-mercaptopropionic acid (GAD inhibitor) treatment did not affect GABAB receptor expressions. These findings suggest that GABAB receptor expression in the gerbil hippocampus may be altered by baclofen or phaclofen treatment.

KW - 3-MPA

KW - Baclofen

KW - Epilepsy

KW - GABA receptor

KW - Gerbil

KW - Hippocampus

KW - Phaclofen

KW - Seizure

KW - Vigabatrin

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U2 - 10.1016/j.neures.2004.05.004

DO - 10.1016/j.neures.2004.05.004

M3 - Article

C2 - 15236866

AN - SCOPUS:4644244381

SN - 0168-0102

VL - 49

SP - 405

EP - 416

JO - Neuroscience Research

JF - Neuroscience Research

IS - 4

ER -

Altered GABA_B receptor immunoreactivity in the gerbil hippocampus induced by baclofen and phaclofen, not seizure activity

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