Ameliorative effect of atractylenolide III in the mast cell proliferation induced by TSLP

Myoung schook Yoou; Sun Young Nam; Mu Hyun Jin; So Young Lee; Mi Sun Kim; Seok Seon Roh; In Hwa Choi; Nariyah Woo; Seok Won Lim; Dong Hyun Kim; Jae Bum Jang; Hyung Min Kim; Hyun Ja Jeong

doi:10.1016/j.fct.2017.05.042

Ameliorative effect of atractylenolide III in the mast cell proliferation induced by TSLP

Myoung schook Yoou, Sun Young Nam, Mu Hyun Jin, So Young Lee, Mi Sun Kim, Seok Seon Roh, In Hwa Choi, Nariyah Woo, Seok Won Lim, Dong Hyun Kim, Jae Bum Jang, Hyung Min Kim, Hyun Ja Jeong

Department of Innovative Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Atractylenolide III (ATL-III) is an active compound of Atractylodes lancea, which has been widely used for the treatment of cancer. Cancer is closely connected with inflammation, and many anti-inflammatory agents are also used to treat cancer. We investigated the influence of ATL-III on thymic stromal lymphopoietin (TSLP)-induced inflammatory reactions. Pretreatment with ATL-III suppressed murine double minute 2 levels and promoted p53 levels in TSLP-treated human mast cell, HMC-1 cells. Mast cell proliferation increased by TSLP or IL-3 stimulation was significantly decreased by ATL-III pretreatment. Interleukin (IL)-13 and phosphorylated signal transducer and activator of transcription 3, 5, and 6 levels in TSLP-treated HMC-1 cells were also decreased by ATL-III pretreatment. In addition, ATL-III decreased the TSLP-induced production of proinflammatory cytokines (IL-6, IL-1β, tumor necrosis factor-α, and IL-8). ATL-III decreased the levels of Bcl2 and procaspase-3 and increased caspase-3 activation and cleaved PARP levels. Furthermore, ATL-III decreased TSLP-induced mast cell proliferation and the production of inflammatory cytokine by LAD2 cells. Taken together, these findings suggest that ATL-III plays a useful role as an anti-inflammatory agent and should be viewed as a potential anti-cancer agent.

Original language	English
Pages (from-to)	78-85
Number of pages	8
Journal	Food and Chemical Toxicology
Volume	106
DOIs	https://doi.org/10.1016/j.fct.2017.05.042
State	Published - Aug 2017

Keywords

Atractylenolide III
Interleukin-13
Mast cell
Murine double minute 2
Signal transducer and activator of transcription 6
Thymic stromal lymphopoietin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fct.2017.05.042

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@article{e0caacef2a5d4c688a9faafc12d6fe9d,

title = "Ameliorative effect of atractylenolide III in the mast cell proliferation induced by TSLP",

abstract = "Atractylenolide III (ATL-III) is an active compound of Atractylodes lancea, which has been widely used for the treatment of cancer. Cancer is closely connected with inflammation, and many anti-inflammatory agents are also used to treat cancer. We investigated the influence of ATL-III on thymic stromal lymphopoietin (TSLP)-induced inflammatory reactions. Pretreatment with ATL-III suppressed murine double minute 2 levels and promoted p53 levels in TSLP-treated human mast cell, HMC-1 cells. Mast cell proliferation increased by TSLP or IL-3 stimulation was significantly decreased by ATL-III pretreatment. Interleukin (IL)-13 and phosphorylated signal transducer and activator of transcription 3, 5, and 6 levels in TSLP-treated HMC-1 cells were also decreased by ATL-III pretreatment. In addition, ATL-III decreased the TSLP-induced production of proinflammatory cytokines (IL-6, IL-1β, tumor necrosis factor-α, and IL-8). ATL-III decreased the levels of Bcl2 and procaspase-3 and increased caspase-3 activation and cleaved PARP levels. Furthermore, ATL-III decreased TSLP-induced mast cell proliferation and the production of inflammatory cytokine by LAD2 cells. Taken together, these findings suggest that ATL-III plays a useful role as an anti-inflammatory agent and should be viewed as a potential anti-cancer agent.",

keywords = "Atractylenolide III, Interleukin-13, Mast cell, Murine double minute 2, Signal transducer and activator of transcription 6, Thymic stromal lymphopoietin",

author = "Yoou, {Myoung schook} and Nam, {Sun Young} and Jin, {Mu Hyun} and Lee, {So Young} and Kim, {Mi Sun} and Roh, {Seok Seon} and Choi, {In Hwa} and Nariyah Woo and Lim, {Seok Won} and Kim, {Dong Hyun} and Jang, {Jae Bum} and Kim, {Hyung Min} and Jeong, {Hyun Ja}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

month = aug,

doi = "10.1016/j.fct.2017.05.042",

language = "English",

volume = "106",

pages = "78--85",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Ameliorative effect of atractylenolide III in the mast cell proliferation induced by TSLP

AU - Yoou, Myoung schook

AU - Nam, Sun Young

AU - Jin, Mu Hyun

AU - Lee, So Young

AU - Kim, Mi Sun

AU - Roh, Seok Seon

AU - Choi, In Hwa

AU - Woo, Nariyah

AU - Lim, Seok Won

AU - Kim, Dong Hyun

AU - Jang, Jae Bum

AU - Kim, Hyung Min

AU - Jeong, Hyun Ja

PY - 2017/8

Y1 - 2017/8

N2 - Atractylenolide III (ATL-III) is an active compound of Atractylodes lancea, which has been widely used for the treatment of cancer. Cancer is closely connected with inflammation, and many anti-inflammatory agents are also used to treat cancer. We investigated the influence of ATL-III on thymic stromal lymphopoietin (TSLP)-induced inflammatory reactions. Pretreatment with ATL-III suppressed murine double minute 2 levels and promoted p53 levels in TSLP-treated human mast cell, HMC-1 cells. Mast cell proliferation increased by TSLP or IL-3 stimulation was significantly decreased by ATL-III pretreatment. Interleukin (IL)-13 and phosphorylated signal transducer and activator of transcription 3, 5, and 6 levels in TSLP-treated HMC-1 cells were also decreased by ATL-III pretreatment. In addition, ATL-III decreased the TSLP-induced production of proinflammatory cytokines (IL-6, IL-1β, tumor necrosis factor-α, and IL-8). ATL-III decreased the levels of Bcl2 and procaspase-3 and increased caspase-3 activation and cleaved PARP levels. Furthermore, ATL-III decreased TSLP-induced mast cell proliferation and the production of inflammatory cytokine by LAD2 cells. Taken together, these findings suggest that ATL-III plays a useful role as an anti-inflammatory agent and should be viewed as a potential anti-cancer agent.

AB - Atractylenolide III (ATL-III) is an active compound of Atractylodes lancea, which has been widely used for the treatment of cancer. Cancer is closely connected with inflammation, and many anti-inflammatory agents are also used to treat cancer. We investigated the influence of ATL-III on thymic stromal lymphopoietin (TSLP)-induced inflammatory reactions. Pretreatment with ATL-III suppressed murine double minute 2 levels and promoted p53 levels in TSLP-treated human mast cell, HMC-1 cells. Mast cell proliferation increased by TSLP or IL-3 stimulation was significantly decreased by ATL-III pretreatment. Interleukin (IL)-13 and phosphorylated signal transducer and activator of transcription 3, 5, and 6 levels in TSLP-treated HMC-1 cells were also decreased by ATL-III pretreatment. In addition, ATL-III decreased the TSLP-induced production of proinflammatory cytokines (IL-6, IL-1β, tumor necrosis factor-α, and IL-8). ATL-III decreased the levels of Bcl2 and procaspase-3 and increased caspase-3 activation and cleaved PARP levels. Furthermore, ATL-III decreased TSLP-induced mast cell proliferation and the production of inflammatory cytokine by LAD2 cells. Taken together, these findings suggest that ATL-III plays a useful role as an anti-inflammatory agent and should be viewed as a potential anti-cancer agent.

KW - Atractylenolide III

KW - Interleukin-13

KW - Mast cell

KW - Murine double minute 2

KW - Signal transducer and activator of transcription 6

KW - Thymic stromal lymphopoietin

UR - http://www.scopus.com/inward/record.url?scp=85019904994&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2017.05.042

DO - 10.1016/j.fct.2017.05.042

M3 - Article

C2 - 28545868

AN - SCOPUS:85019904994

SN - 0278-6915

VL - 106

SP - 78

EP - 85

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

Ameliorative effect of atractylenolide III in the mast cell proliferation induced by TSLP

Abstract

Keywords

UN SDGs

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