An indole-based fluorescent chemosensor targeting the autophagosome

Sun Young Park; Kyutae Kim; Dong Hyung Cho; Eun Young Jo; Chulhun Kang; Min Hee Lee

doi:10.1039/d1cc06681a

An indole-based fluorescent chemosensor targeting the autophagosome

Sun Young Park, Kyutae Kim, Dong Hyung Cho, Eun Young Jo, Chulhun Kang, Min Hee Lee

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Autophagy is a process for the degradation and recycling of intracellular components and dysfunctional organelles. We developed an indole-embedded fluorescent naphthalimide for the selective imaging of autophagosomes in live cells. It was shown as intense puncta in the fluorescence confocal images and co-localizes with an autophagosome marker, LC3-RFP. In addition, it was applied to cellular autophagic models based on ER stress and starvation to verify its capability.

Original language	English
Pages (from-to)	2886-2889
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	17
DOIs	https://doi.org/10.1039/d1cc06681a
State	Published - 28 Feb 2022

Access to Document

10.1039/d1cc06681a

Cite this

@article{40bfb4ff026444e08da102e45dec25b1,

title = "An indole-based fluorescent chemosensor targeting the autophagosome",

abstract = "Autophagy is a process for the degradation and recycling of intracellular components and dysfunctional organelles. We developed an indole-embedded fluorescent naphthalimide for the selective imaging of autophagosomes in live cells. It was shown as intense puncta in the fluorescence confocal images and co-localizes with an autophagosome marker, LC3-RFP. In addition, it was applied to cellular autophagic models based on ER stress and starvation to verify its capability.",

author = "Park, {Sun Young} and Kyutae Kim and Cho, {Dong Hyung} and Jo, {Eun Young} and Chulhun Kang and Lee, {Min Hee}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2022",

month = feb,

day = "28",

doi = "10.1039/d1cc06681a",

language = "English",

volume = "58",

pages = "2886--2889",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "17",

}

TY - JOUR

T1 - An indole-based fluorescent chemosensor targeting the autophagosome

AU - Park, Sun Young

AU - Kim, Kyutae

AU - Cho, Dong Hyung

AU - Jo, Eun Young

AU - Kang, Chulhun

AU - Lee, Min Hee

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2022/2/28

Y1 - 2022/2/28

N2 - Autophagy is a process for the degradation and recycling of intracellular components and dysfunctional organelles. We developed an indole-embedded fluorescent naphthalimide for the selective imaging of autophagosomes in live cells. It was shown as intense puncta in the fluorescence confocal images and co-localizes with an autophagosome marker, LC3-RFP. In addition, it was applied to cellular autophagic models based on ER stress and starvation to verify its capability.

AB - Autophagy is a process for the degradation and recycling of intracellular components and dysfunctional organelles. We developed an indole-embedded fluorescent naphthalimide for the selective imaging of autophagosomes in live cells. It was shown as intense puncta in the fluorescence confocal images and co-localizes with an autophagosome marker, LC3-RFP. In addition, it was applied to cellular autophagic models based on ER stress and starvation to verify its capability.

UR - http://www.scopus.com/inward/record.url?scp=85125212023&partnerID=8YFLogxK

U2 - 10.1039/d1cc06681a

DO - 10.1039/d1cc06681a

M3 - Article

C2 - 35133354

AN - SCOPUS:85125212023

SN - 1359-7345

VL - 58

SP - 2886

EP - 2889

JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

An indole-based fluorescent chemosensor targeting the autophagosome

Abstract

Access to Document

Other files and links

Fingerprint

Cite this