An indole-based fluorescent chemosensor targeting the autophagosome

Sun Young Park; Kyutae Kim; Dong Hyung Cho; Eun Young Jo; Chulhun Kang; Min Hee Lee

doi:10.1039/d1cc06681a

An indole-based fluorescent chemosensor targeting the autophagosome

Sun Young Park
, Kyutae Kim
, Dong Hyung Cho
, Eun Young Jo
, Chulhun Kang
, Min Hee Lee

Sookmyung Women's University
Kyung Hee University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Autophagy is a process for the degradation and recycling of intracellular components and dysfunctional organelles. We developed an indole-embedded fluorescent naphthalimide for the selective imaging of autophagosomes in live cells. It was shown as intense puncta in the fluorescence confocal images and co-localizes with an autophagosome marker, LC3-RFP. In addition, it was applied to cellular autophagic models based on ER stress and starvation to verify its capability.

Original language	English
Pages (from-to)	2886-2889
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	17
DOIs	https://doi.org/10.1039/d1cc06681a
State	Published - 28 Feb 2022

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10.1039/d1cc06681a

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title = "An indole-based fluorescent chemosensor targeting the autophagosome",

abstract = "Autophagy is a process for the degradation and recycling of intracellular components and dysfunctional organelles. We developed an indole-embedded fluorescent naphthalimide for the selective imaging of autophagosomes in live cells. It was shown as intense puncta in the fluorescence confocal images and co-localizes with an autophagosome marker, LC3-RFP. In addition, it was applied to cellular autophagic models based on ER stress and starvation to verify its capability.",

author = "Park, \{Sun Young\} and Kyutae Kim and Cho, \{Dong Hyung\} and Jo, \{Eun Young\} and Chulhun Kang and Lee, \{Min Hee\}",

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AU - Park, Sun Young

AU - Kim, Kyutae

AU - Cho, Dong Hyung

AU - Jo, Eun Young

AU - Kang, Chulhun

AU - Lee, Min Hee

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2022/2/28

Y1 - 2022/2/28

N2 - Autophagy is a process for the degradation and recycling of intracellular components and dysfunctional organelles. We developed an indole-embedded fluorescent naphthalimide for the selective imaging of autophagosomes in live cells. It was shown as intense puncta in the fluorescence confocal images and co-localizes with an autophagosome marker, LC3-RFP. In addition, it was applied to cellular autophagic models based on ER stress and starvation to verify its capability.

AB - Autophagy is a process for the degradation and recycling of intracellular components and dysfunctional organelles. We developed an indole-embedded fluorescent naphthalimide for the selective imaging of autophagosomes in live cells. It was shown as intense puncta in the fluorescence confocal images and co-localizes with an autophagosome marker, LC3-RFP. In addition, it was applied to cellular autophagic models based on ER stress and starvation to verify its capability.

UR - https://www.scopus.com/pages/publications/85125212023

U2 - 10.1039/d1cc06681a

DO - 10.1039/d1cc06681a

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SP - 2886

EP - 2889

JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

An indole-based fluorescent chemosensor targeting the autophagosome

Abstract

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