TY - JOUR
T1 - Analysis of polyphenolic metabolites from artemisia gmelinii weber ex stechm. And regional comparison in Korea
AU - Park, Mi Hyeon
AU - Kim, Doo Young
AU - Jang, Hyun Jae
AU - Jo, Yang Hee
AU - Jeong, Jin Tae
AU - Lee, Dae Young
AU - Baek, Nam In
AU - Ryu, Hyung Won
AU - Oh, Sei Ryang
N1 - Publisher Copyright:
© The Korean Society for Applied Biological Chemistry 2019.
PY - 2019
Y1 - 2019
N2 - Artemisia species are widely used as food ingredients and raw material in traditional medicine. However, to date, the secondary metabolites of Artemisia gmelinii Weber ex Stechm. have not been sufficiently investigated. The secondary metabolites of A. gmelinii, which was collected from representative regions in Chungbuk, Gangwon, and Gyeongbuk, were analyzed using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTof MS) combined with an unsupervised principal component analysis (PCA) multivariate analysis. In the loading scatter plot of PCA, significant changes in metabolites were observed between the regions, ten metabolites (3: 5-O-caffeoylquinic acid, 4: 4-O-caffeoylquinic acid, 8: trans-melilotoside, 12: quercetin 3-O-hexoside, 15: 3,4-O-dicaffeoylquinic acid, 17: 3,5-O-dicaffeoylquinic acid, 18: 4,5-O-dicaffeoylquinic acid, 19: syringaldehyde, 20: caffeoylquinic acid derivative, and 23: icariside II) were evaluated as key markers among twenty–five identified metabolites. Interestingly, the contents of the identified marker significantly differed between the three groups. This is the first study to report the presence of marker metabolites and their correlating geographical cultivation in A. gmelinii.
AB - Artemisia species are widely used as food ingredients and raw material in traditional medicine. However, to date, the secondary metabolites of Artemisia gmelinii Weber ex Stechm. have not been sufficiently investigated. The secondary metabolites of A. gmelinii, which was collected from representative regions in Chungbuk, Gangwon, and Gyeongbuk, were analyzed using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTof MS) combined with an unsupervised principal component analysis (PCA) multivariate analysis. In the loading scatter plot of PCA, significant changes in metabolites were observed between the regions, ten metabolites (3: 5-O-caffeoylquinic acid, 4: 4-O-caffeoylquinic acid, 8: trans-melilotoside, 12: quercetin 3-O-hexoside, 15: 3,4-O-dicaffeoylquinic acid, 17: 3,5-O-dicaffeoylquinic acid, 18: 4,5-O-dicaffeoylquinic acid, 19: syringaldehyde, 20: caffeoylquinic acid derivative, and 23: icariside II) were evaluated as key markers among twenty–five identified metabolites. Interestingly, the contents of the identified marker significantly differed between the three groups. This is the first study to report the presence of marker metabolites and their correlating geographical cultivation in A. gmelinii.
KW - Artemisia gmelinii
KW - Caffeoylquinic acid
KW - Metabolites
KW - Region
KW - Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry
UR - http://www.scopus.com/inward/record.url?scp=85077219645&partnerID=8YFLogxK
U2 - 10.3839/jabc.2019.059
DO - 10.3839/jabc.2019.059
M3 - Article
AN - SCOPUS:85077219645
SN - 1976-0442
VL - 62
SP - 433
EP - 439
JO - Journal of Applied Biological Chemistry
JF - Journal of Applied Biological Chemistry
IS - 4
ER -