Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Kyoung Seong Choi; Dennis J. Grab; J. Stephen Dumler

doi:10.1128/IAI.72.6.3680-3683.2004

Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Kyoung Seong Choi, Dennis J. Grab, J. Stephen Dumler

Johns Hopkins University

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33 Scopus citations

Abstract

Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

Original language	English
Pages (from-to)	3680-3683
Number of pages	4
Journal	Infection and Immunity
Volume	72
Issue number	6
DOIs	https://doi.org/10.1128/IAI.72.6.3680-3683.2004
State	Published - Jun 2004

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10.1128/IAI.72.6.3680-3683.2004

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title = "Anaplasma phagocytophilum infection induces protracted neutrophil degranulation",

abstract = "Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.",

author = "Choi, {Kyoung Seong} and Grab, {Dennis J.} and Dumler, {J. Stephen}",

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AU - Dumler, J. Stephen

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AB - Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

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ER -

Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Abstract

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