Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Kyoung Seong Choi; Dennis J. Grab; J. Stephen Dumler

doi:10.1128/IAI.72.6.3680-3683.2004

Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Kyoung Seong Choi
, Dennis J. Grab
, J. Stephen Dumler

Johns Hopkins University

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

Original language	English
Pages (from-to)	3680-3683
Number of pages	4
Journal	Infection and Immunity
Volume	72
Issue number	6
DOIs	https://doi.org/10.1128/IAI.72.6.3680-3683.2004
State	Published - Jun 2004

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10.1128/IAI.72.6.3680-3683.2004

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title = "Anaplasma phagocytophilum infection induces protracted neutrophil degranulation",

abstract = "Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.",

author = "Choi, \{Kyoung Seong\} and Grab, \{Dennis J.\} and Dumler, \{J. Stephen\}",

year = "2004",

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AU - Choi, Kyoung Seong

AU - Grab, Dennis J.

AU - Dumler, J. Stephen

PY - 2004/6

Y1 - 2004/6

N2 - Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

AB - Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

UR - https://www.scopus.com/pages/publications/2542576378

U2 - 10.1128/IAI.72.6.3680-3683.2004

DO - 10.1128/IAI.72.6.3680-3683.2004

M3 - Article

C2 - 15155684

AN - SCOPUS:2542576378

SN - 0019-9567

VL - 72

SP - 3680

EP - 3683

JO - Infection and Immunity

JF - Infection and Immunity

IS - 6

ER -

Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Abstract

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