TY - JOUR
T1 - Anti-allergic and cytotoxic effects of sesquiterpenoids and phenylpropanoids isolated from magnolia biondii
AU - Nguyen, Thi Tuyet Mai
AU - Nguyen, Thi Thu
AU - Lee, Hyun Su
AU - Lee, Bomi
AU - Min, Byung Sun
AU - Kim, Jeong Ah
PY - 2017/10
Y1 - 2017/10
N2 - Ten sesquiterpenoids (1-10) and six phenylpropanoid derivatives (11-16) were isolated from the flower buds of Magnolia biondii Pamp. Their structures were determined by 1D- and 2D-NMR spectroscopy, mass spectrometry, and optical rotation. To evaluate their anti-allergic properties, the inhibitory effect of each isolate (1-16) on interleukin-2 (IL-2) gene expression was examined in Jurkat T cells. Among the isolated compounds, three sesquiterpenoids (2, 5, and 7) and two monoterpenoids (12 and 13) strongly inhibited IL-2 production in Jurkat T cells. Four compounds, (-)-parthenolide (2), eudesm-4(15)-eno-1β,6α-diol (5), biondinin D (12), and tiliroside (16), showed cytotoxicity against Jurkat T cells. In addition, (-)-parthenolide (2) exhibited cytotoxicity against the human cervical cancer HeLa cell line, the human breast cancer MCF-7, and human promyelocytic leukemia HL-60 cell lines.
AB - Ten sesquiterpenoids (1-10) and six phenylpropanoid derivatives (11-16) were isolated from the flower buds of Magnolia biondii Pamp. Their structures were determined by 1D- and 2D-NMR spectroscopy, mass spectrometry, and optical rotation. To evaluate their anti-allergic properties, the inhibitory effect of each isolate (1-16) on interleukin-2 (IL-2) gene expression was examined in Jurkat T cells. Among the isolated compounds, three sesquiterpenoids (2, 5, and 7) and two monoterpenoids (12 and 13) strongly inhibited IL-2 production in Jurkat T cells. Four compounds, (-)-parthenolide (2), eudesm-4(15)-eno-1β,6α-diol (5), biondinin D (12), and tiliroside (16), showed cytotoxicity against Jurkat T cells. In addition, (-)-parthenolide (2) exhibited cytotoxicity against the human cervical cancer HeLa cell line, the human breast cancer MCF-7, and human promyelocytic leukemia HL-60 cell lines.
KW - Anti-allergy
KW - Cytotoxicity
KW - IL-2
KW - Magnolia biondii
KW - Magnoliaceae
UR - http://www.scopus.com/inward/record.url?scp=85032372916&partnerID=8YFLogxK
U2 - 10.1177/1934578x1701201005
DO - 10.1177/1934578x1701201005
M3 - Article
AN - SCOPUS:85032372916
SN - 1934-578X
VL - 12
SP - 1543
EP - 1545
JO - Natural Product Communications
JF - Natural Product Communications
IS - 10
ER -