Anti-allergic inflammatory triterpenoids isolated from the spikes of prunella vulgaris

Hyun Gyu Choi; Tae Hoon Kim; Sang Hyun Kim; Jeong Ah Kim

doi:10.1177/1934578x1601100111

Anti-allergic inflammatory triterpenoids isolated from the spikes of prunella vulgaris

Hyun Gyu Choi, Tae Hoon Kim, Sang Hyun Kim, Jeong Ah Kim

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10 Scopus citations

Abstract

Twelve known triterpenoids (1-12) and two steroids (13 and 14) have been isolated from the spike of the plant Prunella vulgaris. Among them, 2α,3α,23- trihydroxyursa-12,20(30)-dien-28-oic acid (10) was isolated for the first time from this plant. All isolates were evaluated for their inhibitory effect on the gene expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and release of histamine in human mast cells. β-Amyrin (5), 10, and euscaphic acid (12) showed suppression of histamine release with percentage inhibitions of 46.7, 57.9, and 54.2%, respectively. In addition, 5 and 10 showed strong inhibition of TNF-α and IL-6 in the test for pro-inflammatory cytokines. Our results suggest that compounds 5 and 10 largely contribute to the anti-allergic inflammatory effect of P. vulgaris.

Original language	English
Pages (from-to)	31-32
Number of pages	2
Journal	Natural Product Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1177/1934578x1601100111
State	Published - 23 Jan 2016

Keywords

Anti-allergic inflammatory
IL-6
Prunella vulgaris
TNF-α
Triterpene

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title = "Anti-allergic inflammatory triterpenoids isolated from the spikes of prunella vulgaris",

abstract = "Twelve known triterpenoids (1-12) and two steroids (13 and 14) have been isolated from the spike of the plant Prunella vulgaris. Among them, 2α,3α,23- trihydroxyursa-12,20(30)-dien-28-oic acid (10) was isolated for the first time from this plant. All isolates were evaluated for their inhibitory effect on the gene expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and release of histamine in human mast cells. β-Amyrin (5), 10, and euscaphic acid (12) showed suppression of histamine release with percentage inhibitions of 46.7, 57.9, and 54.2%, respectively. In addition, 5 and 10 showed strong inhibition of TNF-α and IL-6 in the test for pro-inflammatory cytokines. Our results suggest that compounds 5 and 10 largely contribute to the anti-allergic inflammatory effect of P. vulgaris.",

keywords = "Anti-allergic inflammatory, IL-6, Prunella vulgaris, TNF-α, Triterpene",

author = "Choi, {Hyun Gyu} and Kim, {Tae Hoon} and Kim, {Sang Hyun} and Kim, {Jeong Ah}",

year = "2016",

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doi = "10.1177/1934578x1601100111",

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AU - Choi, Hyun Gyu

AU - Kim, Tae Hoon

AU - Kim, Sang Hyun

AU - Kim, Jeong Ah

PY - 2016/1/23

Y1 - 2016/1/23

N2 - Twelve known triterpenoids (1-12) and two steroids (13 and 14) have been isolated from the spike of the plant Prunella vulgaris. Among them, 2α,3α,23- trihydroxyursa-12,20(30)-dien-28-oic acid (10) was isolated for the first time from this plant. All isolates were evaluated for their inhibitory effect on the gene expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and release of histamine in human mast cells. β-Amyrin (5), 10, and euscaphic acid (12) showed suppression of histamine release with percentage inhibitions of 46.7, 57.9, and 54.2%, respectively. In addition, 5 and 10 showed strong inhibition of TNF-α and IL-6 in the test for pro-inflammatory cytokines. Our results suggest that compounds 5 and 10 largely contribute to the anti-allergic inflammatory effect of P. vulgaris.

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KW - Anti-allergic inflammatory

KW - IL-6

KW - Prunella vulgaris

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Anti-allergic inflammatory triterpenoids isolated from the spikes of prunella vulgaris

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Keywords

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