Anti-angiogenic activity of conjugated linoleic acid on basic fibroblast growth factor-induced angiogenesis

Eun Joung Moon, You Mie Lee, Kyu Won Kim

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Conjugated linoleic acid (CLA) is a potent inhibitor of mammary carcinogenesis. Cancer cells produce various angiogenic factors which stimulate host vascular endothelial cell mitogenesis and Chemotaxis for their growth and metastasis. Basic fibroblast growth factor (bFGF) is a potent angiogenic factor that is expressed in many tumors. In this study, we found that CLA decreased bFGF-induced endothelial cell proliferation and DNA synthesis in a dose-dependent manner. However, CLA did not inhibit endothelial cell migration. Furthermore, CLA showed a potent inhibitory effect on embryonic vasculogenesis and bFGF-induced angiogenesis in vivo. Collectively, these results suggest that CLA selectively inhibits the active proliferating endothelial cells induced by bFGF, which may explain its anti-carcinogenic properties in vivo.

Original languageEnglish
Pages (from-to)617-621
Number of pages5
JournalOncology Reports
Volume10
Issue number3
StatePublished - May 2003

Keywords

  • Angiogenesis
  • Basic fibroblast growth factor
  • Conjugated linoleic acid
  • Proliferation

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