Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

Dong Gun Lee; Yoonkyung Park; Mi Ran Kim; Hyun Jun Jung; Young Bae Seu; Kyung Soo Hahm; Eun Rhan Woo

doi:10.1023/B:BILE.0000035483.85790.f7

Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

Dong Gun Lee, Yoonkyung Park, Mi Ran Kim, Hyun Jun Jung, Young Bae Seu, Kyung Soo Hahm, Eun Rhan Woo

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114 Scopus citations

Abstract

Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N- feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 μg ml ^-1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml ^-1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

Original language	English
Pages (from-to)	1125-1130
Number of pages	6
Journal	Biotechnology Letters
Volume	26
Issue number	14
DOIs	https://doi.org/10.1023/B:BILE.0000035483.85790.f7
State	Published - Jul 2004

Keywords

anti-fungal activity
dihydro-N-caffeoyltyramine
Lycium chinense
Solanaceae
trans-N-caffeoyltyramine
trans-N-feruloyloctopamine

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10.1023/B:BILE.0000035483.85790.f7

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title = "Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense",

abstract = "Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N- feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 μg ml -1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml -1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.",

keywords = "anti-fungal activity, dihydro-N-caffeoyltyramine, Lycium chinense, Solanaceae, trans-N-caffeoyltyramine, trans-N-feruloyloctopamine",

author = "Lee, {Dong Gun} and Yoonkyung Park and Kim, {Mi Ran} and Jung, {Hyun Jun} and Seu, {Young Bae} and Hahm, {Kyung Soo} and Woo, {Eun Rhan}",

year = "2004",

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doi = "10.1023/B:BILE.0000035483.85790.f7",

language = "English",

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pages = "1125--1130",

journal = "Biotechnology Letters",

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T1 - Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

AU - Lee, Dong Gun

AU - Park, Yoonkyung

AU - Kim, Mi Ran

AU - Jung, Hyun Jun

AU - Seu, Young Bae

AU - Hahm, Kyung Soo

AU - Woo, Eun Rhan

PY - 2004/7

Y1 - 2004/7

N2 - Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N- feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 μg ml -1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml -1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

AB - Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N- feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 μg ml -1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml -1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

KW - anti-fungal activity

KW - dihydro-N-caffeoyltyramine

KW - Lycium chinense

KW - Solanaceae

KW - trans-N-caffeoyltyramine

KW - trans-N-feruloyloctopamine

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SN - 0141-5492

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SP - 1125

EP - 1130

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 14

ER -

Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

Abstract

Keywords

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