Anti-inflammatory activity of Motherwort (Leonurus sibiricus L.)

Hye Young Shin, Sang Hyun Kim, Sin Myoung Kang, Ik Jun Chang, Sang Yong Kim, Hoon Jeon, Kang Hyun Leem, Won Hwan Park, Jong Pil Lim, Tae Yong Shin

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Motherwort (MW), a Korean folk medicine, has been applied to treat inflammatory disease. However, its effect on inflammatory cytokine release from mast cells is not well known. We investigated the anti- inflammatory effect of MW on the secretion of inflammatory cytokine such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 and IL-8 in human mast cell line (HMC-1). MW was treated in vitro before activation of HMC-1 cells with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. MW had no cytotoxic effects on HMC-1 cell viability. MW (1mg/ml) inhibited PMA plus A23187-stimulated gene expression and production of TNF-α, IL-6, and IL-8. Stimulation with PMA plus A23187 induced NF-κB activation in HMC-1 cells, which was inhibited by MW (1mg/ml). MW inhibited secretion of TNF-α, IL-6, and IL-8 possibly by inhibiting NF-κB activation. These results indicate that MW may be helpful in regulating inflammatory diseases.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalImmunopharmacology and Immunotoxicology
Volume31
Issue number2
DOIs
StatePublished - 2009

Keywords

  • Inflammatory cytokine
  • Motherwort
  • NF-κB

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