Abstract
A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.
Original language | English |
---|---|
Pages (from-to) | 481-484 |
Number of pages | 4 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 63 |
Issue number | 6 |
DOIs | |
State | Published - 1 Jun 2015 |
Keywords
- Lindelofidine-1-hydroxymethyl pyrrolizidine
- Madhuca pasquieri
- Sapotaceae