Anti-inflammatory activity of pyrrolizidine alkaloids from the leaves of Madhuca pasquieri (Dubard)

Le Son Hoang, Manh Hung Tran, Joo Sang Lee, Dao Cuong To, Van Thu Nguyen, Jeong Ah Kim, Jeong Hyung Lee, Mi Hee Woo, Byung Sun Min

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.

Original languageEnglish
Pages (from-to)481-484
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume63
Issue number6
DOIs
StatePublished - 1 Jun 2015

Keywords

  • Lindelofidine-1-hydroxymethyl pyrrolizidine
  • Madhuca pasquieri
  • Sapotaceae

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