Anti-inflammatory activity of pyrrolizidine alkaloids from the leaves of Madhuca pasquieri (Dubard)

Le Son Hoang; Manh Hung Tran; Joo Sang Lee; Dao Cuong To; Van Thu Nguyen; Jeong Ah Kim; Jeong Hyung Lee; Mi Hee Woo; Byung Sun Min

doi:10.1248/cpb.c14-00855

Anti-inflammatory activity of pyrrolizidine alkaloids from the leaves of Madhuca pasquieri (Dubard)

Le Son Hoang
, Manh Hung Tran
, Joo Sang Lee
, Dao Cuong To
, Van Thu Nguyen
, Jeong Ah Kim
, Jeong Hyung Lee
, Mi Hee Woo
, Byung Sun Min

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.

Original language	English
Pages (from-to)	481-484
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	63
Issue number	6
DOIs	https://doi.org/10.1248/cpb.c14-00855
State	Published - 1 Jun 2015

Keywords

Lindelofidine-1-hydroxymethyl pyrrolizidine
Madhuca pasquieri
Sapotaceae

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1248/cpb.c14-00855

Cite this

@article{268b10f773294c5cbe4038f753948635,

title = "Anti-inflammatory activity of pyrrolizidine alkaloids from the leaves of Madhuca pasquieri (Dubard)",

abstract = "A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.",

keywords = "Lindelofidine-1-hydroxymethyl pyrrolizidine, Madhuca pasquieri, Sapotaceae",

author = "Hoang, \{Le Son\} and Tran, \{Manh Hung\} and Lee, \{Joo Sang\} and To, \{Dao Cuong\} and Nguyen, \{Van Thu\} and Kim, \{Jeong Ah\} and Lee, \{Jeong Hyung\} and Woo, \{Mi Hee\} and Min, \{Byung Sun\}",

note = "Publisher Copyright: {\textcopyright} 2015 The Pharmaceutical Society of Japan.",

year = "2015",

month = jun,

day = "1",

doi = "10.1248/cpb.c14-00855",

language = "English",

volume = "63",

pages = "481--484",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "6",

}

TY - JOUR

T1 - Anti-inflammatory activity of pyrrolizidine alkaloids from the leaves of Madhuca pasquieri (Dubard)

AU - Hoang, Le Son

AU - Tran, Manh Hung

AU - Lee, Joo Sang

AU - To, Dao Cuong

AU - Nguyen, Van Thu

AU - Kim, Jeong Ah

AU - Lee, Jeong Hyung

AU - Woo, Mi Hee

AU - Min, Byung Sun

PY - 2015/6/1

Y1 - 2015/6/1

N2 - A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.

AB - A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.

KW - Lindelofidine-1-hydroxymethyl pyrrolizidine

KW - Madhuca pasquieri

KW - Sapotaceae

UR - https://www.scopus.com/pages/publications/84940377814

U2 - 10.1248/cpb.c14-00855

DO - 10.1248/cpb.c14-00855

M3 - Article

C2 - 26027474

AN - SCOPUS:84940377814

SN - 0009-2363

VL - 63

SP - 481

EP - 484

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 6

ER -

Anti-inflammatory activity of pyrrolizidine alkaloids from the leaves of Madhuca pasquieri (Dubard)

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this