Anti-inflammatory and antioxidant activities of phenolic compounds from Desmodium caudatum leaves and stems

Wei Li; Ya Nan Sun; Xi Tao Yan; Seo Young Yang; Sohyun Kim; Doobyeong Chae; Jin Won Hyun; Hee Kyoung Kang; Young Sang Koh; Young Ho Kim

doi:10.1007/s12272-013-0241-0

Anti-inflammatory and antioxidant activities of phenolic compounds from Desmodium caudatum leaves and stems

Wei Li, Ya Nan Sun, Xi Tao Yan, Seo Young Yang, Sohyun Kim, Doobyeong Chae, Jin Won Hyun, Hee Kyoung Kang, Young Sang Koh, Young Ho Kim

Department of Biology Education

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Four flavanonols (1-4), one xanthone (5), and three flavonoid glycosides (6-8), were isolated from the leaves and stems of Desmodium caudatum. Their structures were elucidated by comparing spectroscopic data with reported values. The anti-inflammatory activity of the isolated compounds was investigated in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. Among them, compounds 1 and 2 exhibited inhibitory effects on LPS-induced IL-6, IL-12 p40, and TNF-α production with IC₅₀ values ranging from 6.0 to 29.4 μM. Compound 5 exhibited 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species scavenging activity in human HaCaT keratinocytes. These results warrant further studies of the potential anti-inflammatory and antioxidant benefits of compounds from D. caudatum.

Original language	English
Pages (from-to)	721-727
Number of pages	7
Journal	Archives of Pharmacal Research
Volume	37
Issue number	6
DOIs	https://doi.org/10.1007/s12272-013-0241-0
State	Published - Jun 2014

Keywords

Anti-inflammatory
Antioxidant
Desmodium caudatum
Flavonone
Xanthone

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title = "Anti-inflammatory and antioxidant activities of phenolic compounds from Desmodium caudatum leaves and stems",

abstract = "Four flavanonols (1-4), one xanthone (5), and three flavonoid glycosides (6-8), were isolated from the leaves and stems of Desmodium caudatum. Their structures were elucidated by comparing spectroscopic data with reported values. The anti-inflammatory activity of the isolated compounds was investigated in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. Among them, compounds 1 and 2 exhibited inhibitory effects on LPS-induced IL-6, IL-12 p40, and TNF-α production with IC50 values ranging from 6.0 to 29.4 μM. Compound 5 exhibited 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species scavenging activity in human HaCaT keratinocytes. These results warrant further studies of the potential anti-inflammatory and antioxidant benefits of compounds from D. caudatum.",

keywords = "Anti-inflammatory, Antioxidant, Desmodium caudatum, Flavonone, Xanthone",

author = "Wei Li and Sun, {Ya Nan} and Yan, {Xi Tao} and Yang, {Seo Young} and Sohyun Kim and Doobyeong Chae and Hyun, {Jin Won} and Kang, {Hee Kyoung} and Koh, {Young Sang} and Kim, {Young Ho}",

year = "2014",

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doi = "10.1007/s12272-013-0241-0",

language = "English",

volume = "37",

pages = "721--727",

journal = "Archives of Pharmacal Research",

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TY - JOUR

T1 - Anti-inflammatory and antioxidant activities of phenolic compounds from Desmodium caudatum leaves and stems

AU - Li, Wei

AU - Sun, Ya Nan

AU - Yan, Xi Tao

AU - Yang, Seo Young

AU - Kim, Sohyun

AU - Chae, Doobyeong

AU - Hyun, Jin Won

AU - Kang, Hee Kyoung

AU - Koh, Young Sang

AU - Kim, Young Ho

PY - 2014/6

Y1 - 2014/6

N2 - Four flavanonols (1-4), one xanthone (5), and three flavonoid glycosides (6-8), were isolated from the leaves and stems of Desmodium caudatum. Their structures were elucidated by comparing spectroscopic data with reported values. The anti-inflammatory activity of the isolated compounds was investigated in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. Among them, compounds 1 and 2 exhibited inhibitory effects on LPS-induced IL-6, IL-12 p40, and TNF-α production with IC50 values ranging from 6.0 to 29.4 μM. Compound 5 exhibited 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species scavenging activity in human HaCaT keratinocytes. These results warrant further studies of the potential anti-inflammatory and antioxidant benefits of compounds from D. caudatum.

AB - Four flavanonols (1-4), one xanthone (5), and three flavonoid glycosides (6-8), were isolated from the leaves and stems of Desmodium caudatum. Their structures were elucidated by comparing spectroscopic data with reported values. The anti-inflammatory activity of the isolated compounds was investigated in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. Among them, compounds 1 and 2 exhibited inhibitory effects on LPS-induced IL-6, IL-12 p40, and TNF-α production with IC50 values ranging from 6.0 to 29.4 μM. Compound 5 exhibited 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species scavenging activity in human HaCaT keratinocytes. These results warrant further studies of the potential anti-inflammatory and antioxidant benefits of compounds from D. caudatum.

KW - Anti-inflammatory

KW - Antioxidant

KW - Desmodium caudatum

KW - Flavonone

KW - Xanthone

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U2 - 10.1007/s12272-013-0241-0

DO - 10.1007/s12272-013-0241-0

M3 - Article

C2 - 24026429

AN - SCOPUS:84904403599

SN - 0253-6269

VL - 37

SP - 721

EP - 727

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 6

ER -

Anti-inflammatory and antioxidant activities of phenolic compounds from Desmodium caudatum leaves and stems

Abstract

Keywords

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