Anti-Inflammatory Butenolides from a Marine-Derived Streptomyces sp. 13G036

Ming Gao; Sang Bong Lee; Jae Eon Lee; Geum Jin Kim; Jimin Moon; Joo Won Nam; Jong Sup Bae; Jungwook Chin; Yong Hyun Jeon; Hyukjae Choi

doi:10.3390/app12094510

Anti-Inflammatory Butenolides from a Marine-Derived Streptomyces sp. 13G036

Ming Gao, Sang Bong Lee, Jae Eon Lee, Geum Jin Kim, Jimin Moon, Joo Won Nam, Jong Sup Bae, Jungwook Chin, Yong Hyun Jeon, Hyukjae Choi

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Butenolides are a family of lactones containing a double bond and have been frequently found in the extracts of Streptomyces bacterial species with various pharmacological activities. In this study, seven butenolides (1–7) were discovered and isolated from the culture broth of a marine-derived Streptomyces sp. 13G036 based on a molecular networking analysis. Among the seven isolates, compound 7 was first isolated as a natural product in this study. The structures of compounds 1–7 were determined by combined analysis of 1D/2D Nuclear Magnetic Resonance (NMR) spectra, Mass Spectrometry (MS) spectra and electronic circular dichroism (ECD) data. Compounds 1–6 showed potential anti-inflammatory activities by inhibiting the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interleukine-6 (IL-6) in lipopolysaccharide-stimulated macrophages.

Original language	English
Article number	4510
Journal	Applied Sciences (Switzerland)
Volume	12
Issue number	9
DOIs	https://doi.org/10.3390/app12094510
State	Published - 1 May 2022

Keywords

anti-inflammatory activity
butenolide
GNPS
Streptomyces sp

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/app12094510

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title = "Anti-Inflammatory Butenolides from a Marine-Derived Streptomyces sp. 13G036",

abstract = "Butenolides are a family of lactones containing a double bond and have been frequently found in the extracts of Streptomyces bacterial species with various pharmacological activities. In this study, seven butenolides (1–7) were discovered and isolated from the culture broth of a marine-derived Streptomyces sp. 13G036 based on a molecular networking analysis. Among the seven isolates, compound 7 was first isolated as a natural product in this study. The structures of compounds 1–7 were determined by combined analysis of 1D/2D Nuclear Magnetic Resonance (NMR) spectra, Mass Spectrometry (MS) spectra and electronic circular dichroism (ECD) data. Compounds 1–6 showed potential anti-inflammatory activities by inhibiting the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interleukine-6 (IL-6) in lipopolysaccharide-stimulated macrophages.",

keywords = "anti-inflammatory activity, butenolide, GNPS, Streptomyces sp",

author = "Ming Gao and Lee, {Sang Bong} and Lee, {Jae Eon} and Kim, {Geum Jin} and Jimin Moon and Nam, {Joo Won} and Bae, {Jong Sup} and Jungwook Chin and Jeon, {Yong Hyun} and Hyukjae Choi",

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AU - Gao, Ming

AU - Lee, Sang Bong

AU - Lee, Jae Eon

AU - Kim, Geum Jin

AU - Moon, Jimin

AU - Nam, Joo Won

AU - Bae, Jong Sup

AU - Chin, Jungwook

AU - Jeon, Yong Hyun

AU - Choi, Hyukjae

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Butenolides are a family of lactones containing a double bond and have been frequently found in the extracts of Streptomyces bacterial species with various pharmacological activities. In this study, seven butenolides (1–7) were discovered and isolated from the culture broth of a marine-derived Streptomyces sp. 13G036 based on a molecular networking analysis. Among the seven isolates, compound 7 was first isolated as a natural product in this study. The structures of compounds 1–7 were determined by combined analysis of 1D/2D Nuclear Magnetic Resonance (NMR) spectra, Mass Spectrometry (MS) spectra and electronic circular dichroism (ECD) data. Compounds 1–6 showed potential anti-inflammatory activities by inhibiting the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interleukine-6 (IL-6) in lipopolysaccharide-stimulated macrophages.

AB - Butenolides are a family of lactones containing a double bond and have been frequently found in the extracts of Streptomyces bacterial species with various pharmacological activities. In this study, seven butenolides (1–7) were discovered and isolated from the culture broth of a marine-derived Streptomyces sp. 13G036 based on a molecular networking analysis. Among the seven isolates, compound 7 was first isolated as a natural product in this study. The structures of compounds 1–7 were determined by combined analysis of 1D/2D Nuclear Magnetic Resonance (NMR) spectra, Mass Spectrometry (MS) spectra and electronic circular dichroism (ECD) data. Compounds 1–6 showed potential anti-inflammatory activities by inhibiting the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interleukine-6 (IL-6) in lipopolysaccharide-stimulated macrophages.

KW - anti-inflammatory activity

KW - butenolide

KW - GNPS

KW - Streptomyces sp

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DO - 10.3390/app12094510

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SN - 2076-3417

VL - 12

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

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M1 - 4510

ER -

Anti-Inflammatory Butenolides from a Marine-Derived Streptomyces sp. 13G036

Abstract

Keywords

UN SDGs

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