Anti-inflammatory cycloartane-type saponins of astragalus membranaceus

Dae Young Lee; Hyung Jun Noh; Jehun Choi; Kyeong Hee Lee; Min Ho Lee; Ji Hyun Lee; Yoonpyo Hong; Seung Eun Lee; Seung Yu Kim; Geum Soog Kim

doi:10.3390/molecules18043725

Anti-inflammatory cycloartane-type saponins of astragalus membranaceus

Dae Young Lee, Hyung Jun Noh, Jehun Choi, Kyeong Hee Lee, Min Ho Lee, Ji Hyun Lee, Yoonpyo Hong, Seung Eun Lee, Seung Yu Kim, Geum Soog Kim

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O- β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)- 3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (¹H, ¹³C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.

Original language	English
Pages (from-to)	3725-3732
Number of pages	8
Journal	Molecules
Volume	18
Issue number	4
DOIs	https://doi.org/10.3390/molecules18043725
State	Published - Apr 2013

Keywords

Agroastragaloside V
Astragalus membranaceus
Cycloartane-type triterpene
Nitric oxide

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10.3390/molecules18043725

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title = "Anti-inflammatory cycloartane-type saponins of astragalus membranaceus",

abstract = "A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O- β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)- 3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.",

keywords = "Agroastragaloside V, Astragalus membranaceus, Cycloartane-type triterpene, Nitric oxide",

author = "Lee, {Dae Young} and Noh, {Hyung Jun} and Jehun Choi and Lee, {Kyeong Hee} and Lee, {Min Ho} and Lee, {Ji Hyun} and Yoonpyo Hong and Lee, {Seung Eun} and Kim, {Seung Yu} and Kim, {Geum Soog}",

year = "2013",

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AU - Lee, Dae Young

AU - Noh, Hyung Jun

AU - Choi, Jehun

AU - Lee, Kyeong Hee

AU - Lee, Min Ho

AU - Lee, Ji Hyun

AU - Hong, Yoonpyo

AU - Lee, Seung Eun

AU - Kim, Seung Yu

AU - Kim, Geum Soog

PY - 2013/4

Y1 - 2013/4

N2 - A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O- β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)- 3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.

AB - A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O- β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)- 3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.

KW - Agroastragaloside V

KW - Astragalus membranaceus

KW - Cycloartane-type triterpene

KW - Nitric oxide

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JF - Molecules

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ER -

Anti-inflammatory cycloartane-type saponins of astragalus membranaceus

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