Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways

Ying Hao Han; Dong Qin Chen; Mei Hua Jin; Ying Hua Jin; Jing Li; Gui Nan Shen; Wei Long Li; Yi Xi Gong; Ying Ying Mao; Dan Ping Xie; Dong Seok Lee; Li Yun Yu; Sun Uk Kim; Ji Su Kim; Taeho Kwon; Yu Dong Cui; Hu Nan Sun

doi:10.1186/s13765-020-00504-2

Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways

Ying Hao Han, Dong Qin Chen, Mei Hua Jin, Ying Hua Jin, Jing Li, Gui Nan Shen, Wei Long Li, Yi Xi Gong, Ying Ying Mao, Dan Ping Xie, Dong Seok Lee, Li Yun Yu, Sun Uk Kim, Ji Su Kim, Taeho Kwon, Yu Dong Cui, Hu Nan Sun

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13 Scopus citations

Abstract

Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.

Original language	English
Article number	21
Journal	Applied Biological Chemistry
Volume	63
Issue number	1
DOIs	https://doi.org/10.1186/s13765-020-00504-2
State	Published - 1 Dec 2020

Keywords

Hispidin
LPS
Macrophage
ROS
Signal transduction

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10.1186/s13765-020-00504-2

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Han, Y. H., Chen, D. Q., Jin, M. H., Jin, Y. H., Li, J., Shen, G. N., Li, W. L., Gong, Y. X., Mao, Y. Y., Xie, D. P., Lee, D. S., Yu, L. Y., Kim, S. U., Kim, J. S., Kwon, T., Cui, Y. D., & Sun, H. N. (2020). Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways. Applied Biological Chemistry, 63(1), Article 21. https://doi.org/10.1186/s13765-020-00504-2

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title = "Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways",

abstract = "Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.",

keywords = "Hispidin, LPS, Macrophage, ROS, Signal transduction",

author = "Han, {Ying Hao} and Chen, {Dong Qin} and Jin, {Mei Hua} and Jin, {Ying Hua} and Jing Li and Shen, {Gui Nan} and Li, {Wei Long} and Gong, {Yi Xi} and Mao, {Ying Ying} and Xie, {Dan Ping} and Lee, {Dong Seok} and Yu, {Li Yun} and Kim, {Sun Uk} and Kim, {Ji Su} and Taeho Kwon and Cui, {Yu Dong} and Sun, {Hu Nan}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = dec,

day = "1",

doi = "10.1186/s13765-020-00504-2",

language = "English",

volume = "63",

journal = "Applied Biological Chemistry",

issn = "2468-0834",

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number = "1",

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Han, YH, Chen, DQ, Jin, MH, Jin, YH, Li, J, Shen, GN, Li, WL, Gong, YX, Mao, YY, Xie, DP, Lee, DS, Yu, LY, Kim, SU, Kim, JS, Kwon, T, Cui, YD & Sun, HN 2020, 'Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways', Applied Biological Chemistry, vol. 63, no. 1, 21. https://doi.org/10.1186/s13765-020-00504-2

TY - JOUR

T1 - Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways

AU - Han, Ying Hao

AU - Chen, Dong Qin

AU - Jin, Mei Hua

AU - Jin, Ying Hua

AU - Li, Jing

AU - Shen, Gui Nan

AU - Li, Wei Long

AU - Gong, Yi Xi

AU - Mao, Ying Ying

AU - Xie, Dan Ping

AU - Lee, Dong Seok

AU - Yu, Li Yun

AU - Kim, Sun Uk

AU - Kim, Ji Su

AU - Kwon, Taeho

AU - Cui, Yu Dong

AU - Sun, Hu Nan

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.

AB - Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.

KW - Hispidin

KW - LPS

KW - Macrophage

KW - ROS

KW - Signal transduction

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U2 - 10.1186/s13765-020-00504-2

DO - 10.1186/s13765-020-00504-2

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AN - SCOPUS:85084230153

SN - 2468-0834

VL - 63

JO - Applied Biological Chemistry

JF - Applied Biological Chemistry

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ER -

Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways

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