Anti-inflammatory Flavonoids Isolated from Passiflora foetida

Thi Yen Nguyen; Dao Cuong To; Manh Hung Tran; Joo Sang Lee; Jeong Hyung Lee; Jeong Ah Kim; Mi Hee Woo; Byung Sun Min

doi:10.1177/1934578X1501000634

Anti-inflammatory Flavonoids Isolated from Passiflora foetida

Thi Yen Nguyen, Dao Cuong To, Manh Hung Tran, Joo Sang Lee, Jeong Hyung Lee, Jeong Ah Kim, Mi Hee Woo, Byung Sun Min

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

In this study, we evaluated the anti-inflammatory activity of the soluble ethyl acetate fraction and chemical components of the stem bark of Passiflora foetida (Passifloraceae). Ten flavonoids (1–10) were isolated by various chromatographic techniques, and their structures were determined based on spectroscopic analyses by using nuclear magnetic resonance (NMR). Luteolin (2) and chrysoeriol (3) showed the most potent inhibition of nitric oxide (NO) production in macrophage cell line, RAW264.7, with half maximal inhibitor concentration (IC₅₀) values of 1.2 and 3.1 μM, respectively. These compounds suppressed lipopolysaccharide (LPS)-induced inducible NO synthase (iNOS) expression at the transcription level. Our research indicates that the stem bark of P. foetida has significant anti-inflammatory properties, suggesting that its flavonoids may have anti-inflammatory benefits.

Original language	English
Journal	Natural Product Communications
Volume	10
Issue number	6
DOIs	https://doi.org/10.1177/1934578X1501000634
State	Published - 2015

Keywords

Anti-inflammatory activity
Flavonoid
NO Production
Passiflora foetida
Passifloraceae

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10.1177/1934578X1501000634

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title = "Anti-inflammatory Flavonoids Isolated from Passiflora foetida",

abstract = "In this study, we evaluated the anti-inflammatory activity of the soluble ethyl acetate fraction and chemical components of the stem bark of Passiflora foetida (Passifloraceae). Ten flavonoids (1–10) were isolated by various chromatographic techniques, and their structures were determined based on spectroscopic analyses by using nuclear magnetic resonance (NMR). Luteolin (2) and chrysoeriol (3) showed the most potent inhibition of nitric oxide (NO) production in macrophage cell line, RAW264.7, with half maximal inhibitor concentration (IC50) values of 1.2 and 3.1 μM, respectively. These compounds suppressed lipopolysaccharide (LPS)-induced inducible NO synthase (iNOS) expression at the transcription level. Our research indicates that the stem bark of P. foetida has significant anti-inflammatory properties, suggesting that its flavonoids may have anti-inflammatory benefits.",

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AU - Nguyen, Thi Yen

AU - To, Dao Cuong

AU - Tran, Manh Hung

AU - Lee, Joo Sang

AU - Lee, Jeong Hyung

AU - Kim, Jeong Ah

AU - Woo, Mi Hee

AU - Min, Byung Sun

PY - 2015

Y1 - 2015

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AB - In this study, we evaluated the anti-inflammatory activity of the soluble ethyl acetate fraction and chemical components of the stem bark of Passiflora foetida (Passifloraceae). Ten flavonoids (1–10) were isolated by various chromatographic techniques, and their structures were determined based on spectroscopic analyses by using nuclear magnetic resonance (NMR). Luteolin (2) and chrysoeriol (3) showed the most potent inhibition of nitric oxide (NO) production in macrophage cell line, RAW264.7, with half maximal inhibitor concentration (IC50) values of 1.2 and 3.1 μM, respectively. These compounds suppressed lipopolysaccharide (LPS)-induced inducible NO synthase (iNOS) expression at the transcription level. Our research indicates that the stem bark of P. foetida has significant anti-inflammatory properties, suggesting that its flavonoids may have anti-inflammatory benefits.

KW - Anti-inflammatory activity

KW - Flavonoid

KW - NO Production

KW - Passiflora foetida

KW - Passifloraceae

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VL - 10

JO - Natural Product Communications

JF - Natural Product Communications

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ER -

Anti-inflammatory Flavonoids Isolated from Passiflora foetida

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Keywords

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