Anti-inflammatory lignans from the fruits of acanthopanax sessiliflorus

Dae Young Lee; Kyeong Hwa Seo; Rak Hun Jeong; Sang Min Lee; Geum Soog Kim; Hyung Jun Noh; Seung Yu Kim; Gye Won Kim; Ji Young Kim; Nam In Baek

doi:10.3390/molecules18010041

Anti-inflammatory lignans from the fruits of acanthopanax sessiliflorus

Dae Young Lee
, Kyeong Hwa Seo
, Rak Hun Jeong
, Sang Min Lee
, Geum Soog Kim
, Hyung Jun Noh
, Seung Yu Kim
, Gye Won Kim
, Ji Young Kim
, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (¹H, ¹³C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.

Original language	English
Pages (from-to)	41-49
Number of pages	9
Journal	Molecules
Volume	18
Issue number	1
DOIs	https://doi.org/10.3390/molecules18010041
State	Published - Jan 2013

Keywords

Acanthopanax sessiliflorus
Acanthosessilin A
Lignan
Nitric oxide

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10.3390/molecules18010041

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abstract = "A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.",

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doi = "10.3390/molecules18010041",

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AU - Lee, Dae Young

AU - Seo, Kyeong Hwa

AU - Jeong, Rak Hun

AU - Lee, Sang Min

AU - Kim, Geum Soog

AU - Noh, Hyung Jun

AU - Kim, Seung Yu

AU - Kim, Gye Won

AU - Kim, Ji Young

AU - Baek, Nam In

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N2 - A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.

AB - A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.

KW - Acanthopanax sessiliflorus

KW - Acanthosessilin A

KW - Lignan

KW - Nitric oxide

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AN - SCOPUS:84872860662

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SP - 41

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JO - Molecules

JF - Molecules

IS - 1

ER -

Anti-inflammatory lignans from the fruits of acanthopanax sessiliflorus

Abstract

Keywords

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