Anti-influenza diarylheptanoids from the bark of Alnus japonica

Nguyen Huu Tung; Hyuk Joon Kwon; Jae Hong Kim; Jeong Chan Ra; Yan Ding; Jeong Ah Kim; Young Ho Kim

doi:10.1016/j.bmcl.2009.12.057

Anti-influenza diarylheptanoids from the bark of Alnus japonica

Nguyen Huu Tung, Hyuk Joon Kwon, Jae Hong Kim, Jeong Chan Ra, Yan Ding, Jeong Ah Kim, Young Ho Kim

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Abstract

This study to investigate anti-influenza components from the bark of Alnus japonica resulted in the isolation of two rare acylated diarylheptanoids, named oregonoyl A (5) and oregonoyl B (6), along with nine known compounds (1-4 and 7-11). Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Antiviral testing of compounds 1-11 against KBNP-0028 (H9N2) avian influenza virus showed that platyphyllone (10) was strongly active, and platyphyllonol-5-xylopyranoside (9) was moderately active against KBNP-0028 as compared with the positive control, zanamivir, respectively.

Original language	English
Pages (from-to)	1000-1003
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2009.12.057
State	Published - 1 Feb 2010

Keywords

Alnus japonica
Anti-influenza
Betulaceae
Diarylheptanoid
KBNP-0028 (H9N2)

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10.1016/j.bmcl.2009.12.057

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abstract = "This study to investigate anti-influenza components from the bark of Alnus japonica resulted in the isolation of two rare acylated diarylheptanoids, named oregonoyl A (5) and oregonoyl B (6), along with nine known compounds (1-4 and 7-11). Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Antiviral testing of compounds 1-11 against KBNP-0028 (H9N2) avian influenza virus showed that platyphyllone (10) was strongly active, and platyphyllonol-5-xylopyranoside (9) was moderately active against KBNP-0028 as compared with the positive control, zanamivir, respectively.",

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AU - Tung, Nguyen Huu

AU - Kwon, Hyuk Joon

AU - Kim, Jae Hong

AU - Ra, Jeong Chan

AU - Ding, Yan

AU - Kim, Jeong Ah

AU - Kim, Young Ho

PY - 2010/2/1

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AB - This study to investigate anti-influenza components from the bark of Alnus japonica resulted in the isolation of two rare acylated diarylheptanoids, named oregonoyl A (5) and oregonoyl B (6), along with nine known compounds (1-4 and 7-11). Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Antiviral testing of compounds 1-11 against KBNP-0028 (H9N2) avian influenza virus showed that platyphyllone (10) was strongly active, and platyphyllonol-5-xylopyranoside (9) was moderately active against KBNP-0028 as compared with the positive control, zanamivir, respectively.

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KW - Anti-influenza

KW - Betulaceae

KW - Diarylheptanoid

KW - KBNP-0028 (H9N2)

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Anti-influenza diarylheptanoids from the bark of Alnus japonica

Abstract

Keywords

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