Anti-resorptive activity and pharmacokinetic study of N1,N 1-diisopropyl-N2-(diphenylphosphoryl)-2-(4-nitrophenyl) acetamidine

Myung Hee Kim; Mikyung Park; Jin Sook Song; Sang Joon Park; Seong Hwan Kim

doi:10.1016/j.bmcl.2011.05.058

Anti-resorptive activity and pharmacokinetic study of N¹,N ¹-diisopropyl-N²-(diphenylphosphoryl)-2-(4-nitrophenyl) acetamidine

Myung Hee Kim, Mikyung Park, Jin Sook Song, Sang Joon Park, Seong Hwan Kim

Department of Veterinary Medicine

Korea Research Institute of Chemical Technology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In vitro anti-resorptive activity, mechanism of action, pharmacokinetic profile and in vivo anti-resorptive activity of N¹,N ¹-diisopropyl-N²-(diphenylphosphoryl)-2-(4-nitrophenyl) acetamidine (1) were evaluated.

Original language	English
Pages (from-to)	4263-4266
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2011.05.058
State	Published - 15 Jul 2011

Keywords

Bone resorption
Osteoclast
Osteoporosis
Pharmacokinetics
Phosphoryl amidine

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10.1016/j.bmcl.2011.05.058

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title = "Anti-resorptive activity and pharmacokinetic study of N1,N 1-diisopropyl-N2-(diphenylphosphoryl)-2-(4-nitrophenyl) acetamidine",

abstract = "In vitro anti-resorptive activity, mechanism of action, pharmacokinetic profile and in vivo anti-resorptive activity of N1,N 1-diisopropyl-N2-(diphenylphosphoryl)-2-(4-nitrophenyl) acetamidine (1) were evaluated.",

keywords = "Bone resorption, Osteoclast, Osteoporosis, Pharmacokinetics, Phosphoryl amidine",

author = "Kim, {Myung Hee} and Mikyung Park and Song, {Jin Sook} and Park, {Sang Joon} and Kim, {Seong Hwan}",

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AU - Kim, Myung Hee

AU - Park, Mikyung

AU - Song, Jin Sook

AU - Park, Sang Joon

AU - Kim, Seong Hwan

PY - 2011/7/15

Y1 - 2011/7/15

N2 - In vitro anti-resorptive activity, mechanism of action, pharmacokinetic profile and in vivo anti-resorptive activity of N1,N 1-diisopropyl-N2-(diphenylphosphoryl)-2-(4-nitrophenyl) acetamidine (1) were evaluated.

AB - In vitro anti-resorptive activity, mechanism of action, pharmacokinetic profile and in vivo anti-resorptive activity of N1,N 1-diisopropyl-N2-(diphenylphosphoryl)-2-(4-nitrophenyl) acetamidine (1) were evaluated.

KW - Bone resorption

KW - Osteoclast

KW - Osteoporosis

KW - Pharmacokinetics

KW - Phosphoryl amidine

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

Anti-resorptive activity and pharmacokinetic study of N¹,N ¹-diisopropyl-N²-(diphenylphosphoryl)-2-(4-nitrophenyl) acetamidine

Abstract

Keywords

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