Antiallergic and anti-inflammatory effects of the Viticis Fructus

Jin Su You, Byeong Suk Chae, Dae Keun Kim, Xun Cui, Jeong Suk Park, Jae Hyeok Lee, Sang Hyun Kim, Tae Yong Shin

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

This study was carried out to the determine the effects of the water extract of Viticis Fructus (Verbenaceae, WEVF) on experimental allergic reactions and inflammation. WEVF was anally administered to mice for high and fast absorption. WEVF inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E (IgE)-mediated local allergic reaction. Histamine releasing from mast cells was reduced by WEVF, which was mediated by modulation of intracellular calcium. In addition, WEVF decreased the gene expression of pro-inflammatory cytokines in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated HMC-1 cells. These findings demonstrate that the WEVF possesses antiallergic and anti-inflammatory activities, which may be mediated by reducing the release of mediators such as histamine from mast cells and weakening the inflammatory action of these mediators.

Original languageEnglish
Pages (from-to)286-290
Number of pages5
JournalKorean Journal of Pharmacognosy
Volume44
Issue number3
StatePublished - 2013

Keywords

  • Allergic inflammation
  • Histamine
  • Mast cell
  • Pro-inflammatory cytokine
  • Viticis Fructus

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