Antianaphylactic properties of eugenol

Hyung Min Kim; Eun Hee Lee; Chang Young Kim; Jong Gab Chung; Sang Hyun Kim; Jong Pil Lim; Tae Yong Shin

doi:10.1006/phrs.1997.0256

Antianaphylactic properties of eugenol

Hyung Min Kim, Eun Hee Lee, Chang Young Kim, Jong Gab Chung, Sang Hyun Kim, Jong Pil Lim, Tae Yong Shin

Department of Medicine

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The effects of eugenol, a major component of clove, on anaphylaxis were evaluated in rats. Eugenol inhibited compound 48/80-induced systemic anaphylaxis 100% with a dose of 10 μg g^-1 body weight (BW). While serum levels of histamine were markedly elevated after compound 48/80 injection in all groups of rats, rats injected with eugenol showed a significant reduction in serum histamine levels. Eugenol also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Eugenol dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The morphological examination clearly showed that eugenol prevented the anaphylactic degranulation of RPMC. Moreover, Eugenol (10 μg ml^-1) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-α production. These results suggest that eugenol has antianaphylactic properties by preventing mast cell degranulation.

Original language	English
Pages (from-to)	475-480
Number of pages	6
Journal	Pharmacological Research
Volume	36
Issue number	6
DOIs	https://doi.org/10.1006/phrs.1997.0256
State	Published - Dec 1997

Keywords

Anaphylaxis
Eugenol
Histamine
Mast cells
Tumor necrosis factor-α

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10.1006/phrs.1997.0256

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title = "Antianaphylactic properties of eugenol",

abstract = "The effects of eugenol, a major component of clove, on anaphylaxis were evaluated in rats. Eugenol inhibited compound 48/80-induced systemic anaphylaxis 100\% with a dose of 10 μg g-1 body weight (BW). While serum levels of histamine were markedly elevated after compound 48/80 injection in all groups of rats, rats injected with eugenol showed a significant reduction in serum histamine levels. Eugenol also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Eugenol dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The morphological examination clearly showed that eugenol prevented the anaphylactic degranulation of RPMC. Moreover, Eugenol (10 μg ml-1) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-α production. These results suggest that eugenol has antianaphylactic properties by preventing mast cell degranulation.",

keywords = "Anaphylaxis, Eugenol, Histamine, Mast cells, Tumor necrosis factor-α",

author = "Kim, \{Hyung Min\} and Lee, \{Eun Hee\} and Kim, \{Chang Young\} and Chung, \{Jong Gab\} and Kim, \{Sang Hyun\} and Lim, \{Jong Pil\} and Shin, \{Tae Yong\}",

year = "1997",

month = dec,

doi = "10.1006/phrs.1997.0256",

language = "English",

volume = "36",

pages = "475--480",

journal = "Pharmacological Research",

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T1 - Antianaphylactic properties of eugenol

AU - Kim, Hyung Min

AU - Lee, Eun Hee

AU - Kim, Chang Young

AU - Chung, Jong Gab

AU - Kim, Sang Hyun

AU - Lim, Jong Pil

AU - Shin, Tae Yong

PY - 1997/12

Y1 - 1997/12

N2 - The effects of eugenol, a major component of clove, on anaphylaxis were evaluated in rats. Eugenol inhibited compound 48/80-induced systemic anaphylaxis 100% with a dose of 10 μg g-1 body weight (BW). While serum levels of histamine were markedly elevated after compound 48/80 injection in all groups of rats, rats injected with eugenol showed a significant reduction in serum histamine levels. Eugenol also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Eugenol dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The morphological examination clearly showed that eugenol prevented the anaphylactic degranulation of RPMC. Moreover, Eugenol (10 μg ml-1) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-α production. These results suggest that eugenol has antianaphylactic properties by preventing mast cell degranulation.

AB - The effects of eugenol, a major component of clove, on anaphylaxis were evaluated in rats. Eugenol inhibited compound 48/80-induced systemic anaphylaxis 100% with a dose of 10 μg g-1 body weight (BW). While serum levels of histamine were markedly elevated after compound 48/80 injection in all groups of rats, rats injected with eugenol showed a significant reduction in serum histamine levels. Eugenol also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Eugenol dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The morphological examination clearly showed that eugenol prevented the anaphylactic degranulation of RPMC. Moreover, Eugenol (10 μg ml-1) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-α production. These results suggest that eugenol has antianaphylactic properties by preventing mast cell degranulation.

KW - Anaphylaxis

KW - Eugenol

KW - Histamine

KW - Mast cells

KW - Tumor necrosis factor-α

UR - https://www.scopus.com/pages/publications/0031474273

U2 - 10.1006/phrs.1997.0256

DO - 10.1006/phrs.1997.0256

M3 - Article

C2 - 9508673

AN - SCOPUS:0031474273

SN - 1043-6618

VL - 36

SP - 475

EP - 480

JO - Pharmacological Research

JF - Pharmacological Research

IS - 6

ER -

Antianaphylactic properties of eugenol

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Keywords

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