Antibacterial activity of HTI isolated from oriental medicine, Hyungbangjihwang-tang

Woo Sang Sung; Young Bae Seu; Dong Gun Lee

Antibacterial activity of HTI isolated from oriental medicine, Hyungbangjihwang-tang

Woo Sang Sung, Young Bae Seu, Dong Gun Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

Abstract

Hyungbangjihwang-Tang (HT), an Oriental herbal formula, has been known to play a role which helps to recover vigor of human in the Orient. In this study, antibacterial substance (HTI) was purified from the ethyl-acetate extracts of HT by using SiO₂ column chromatography and HPLC, and the antibacterial effects of HTI were investigated. By using the CLSI broth micro-dilution assay, the activity of HTI was evaluated against human pathogenic Gram-positive and Gram-negative bacterial strains including the clinical isolates of methicillin-resistant Staphylococcus aureus. The results demonstrated that HTI showed broad spectrum antibacterial activities against all bacterial strains tested. In conclusion, HTI is an interesting new molecule for its potential in anti-infective drug discovery and for future studies on activity-structure relationship through analysis of its chemical structure.

Original language	English
Pages (from-to)	82-85
Number of pages	4
Journal	Microbiology and Biotechnology Letters
Volume	36
Issue number	1
State	Published - Mar 2008

Keywords

Antibacterial activity
Hyungbangjihwang-Tang
Methicillin-resistant Staphylococcus aureus
Oriental medicine

Cite this

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abstract = "Hyungbangjihwang-Tang (HT), an Oriental herbal formula, has been known to play a role which helps to recover vigor of human in the Orient. In this study, antibacterial substance (HTI) was purified from the ethyl-acetate extracts of HT by using SiO2 column chromatography and HPLC, and the antibacterial effects of HTI were investigated. By using the CLSI broth micro-dilution assay, the activity of HTI was evaluated against human pathogenic Gram-positive and Gram-negative bacterial strains including the clinical isolates of methicillin-resistant Staphylococcus aureus. The results demonstrated that HTI showed broad spectrum antibacterial activities against all bacterial strains tested. In conclusion, HTI is an interesting new molecule for its potential in anti-infective drug discovery and for future studies on activity-structure relationship through analysis of its chemical structure.",

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Antibacterial activity of HTI isolated from oriental medicine, Hyungbangjihwang-tang

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