Antibacterial activity of hylomecon hylomeconoides against methicillin-resistant staphylococcus aureus

Jang Gi Choi; Ok Hwa Kang; Hee Sung Chae; Brice Obiang-Obounou; Young Seob Lee; You Chang Oh; Min San Kim; Dong Won Shin; Jeong Ah Kim; Young Ho Kim; Dong Yeul Kwon

doi:10.1007/s12010-009-8698-5

Antibacterial activity of hylomecon hylomeconoides against methicillin-resistant staphylococcus aureus

Jang Gi Choi, Ok Hwa Kang, Hee Sung Chae, Brice Obiang-Obounou, Young Seob Lee, You Chang Oh, Min San Kim, Dong Won Shin, Jeong Ah Kim, Young Ho Kim, Dong Yeul Kwon

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH₂Cl₂, EtOAc, and H₂O) were investigated against MRSA. The most active extract (CH₂Cl ₂) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 μg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 μg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.

Original language	English
Pages (from-to)	2467-2474
Number of pages	8
Journal	Applied Biochemistry and Biotechnology
Volume	160
Issue number	8
DOIs	https://doi.org/10.1007/s12010-009-8698-5
State	Published - Apr 2010

Keywords

6-Methoxydihydrosanguinarine
Antibacterial
EtOH extract
Hylomecon hylomeconoides
MRSA

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title = "Antibacterial activity of hylomecon hylomeconoides against methicillin-resistant staphylococcus aureus",

abstract = "Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH2Cl2, EtOAc, and H2O) were investigated against MRSA. The most active extract (CH2Cl 2) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 μg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 μg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.",

keywords = "6-Methoxydihydrosanguinarine, Antibacterial, EtOH extract, Hylomecon hylomeconoides, MRSA",

author = "Choi, {Jang Gi} and Kang, {Ok Hwa} and Chae, {Hee Sung} and Brice Obiang-Obounou and Lee, {Young Seob} and Oh, {You Chang} and Kim, {Min San} and Shin, {Dong Won} and Kim, {Jeong Ah} and Kim, {Young Ho} and Kwon, {Dong Yeul}",

year = "2010",

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doi = "10.1007/s12010-009-8698-5",

language = "English",

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T1 - Antibacterial activity of hylomecon hylomeconoides against methicillin-resistant staphylococcus aureus

AU - Choi, Jang Gi

AU - Kang, Ok Hwa

AU - Chae, Hee Sung

AU - Obiang-Obounou, Brice

AU - Lee, Young Seob

AU - Oh, You Chang

AU - Kim, Min San

AU - Shin, Dong Won

AU - Kim, Jeong Ah

AU - Kim, Young Ho

AU - Kwon, Dong Yeul

PY - 2010/4

Y1 - 2010/4

N2 - Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH2Cl2, EtOAc, and H2O) were investigated against MRSA. The most active extract (CH2Cl 2) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 μg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 μg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.

AB - Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH2Cl2, EtOAc, and H2O) were investigated against MRSA. The most active extract (CH2Cl 2) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 μg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 μg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.

KW - 6-Methoxydihydrosanguinarine

KW - Antibacterial

KW - EtOH extract

KW - Hylomecon hylomeconoides

KW - MRSA

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AN - SCOPUS:77949917260

SN - 0273-2289

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SP - 2467

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JO - Applied Biochemistry and Biotechnology

JF - Applied Biochemistry and Biotechnology

IS - 8

ER -

Antibacterial activity of hylomecon hylomeconoides against methicillin-resistant staphylococcus aureus

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Keywords

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