Antibacterial activity of hylomecon hylomeconoides against methicillin-resistant staphylococcus aureus

Jang Gi Choi; Ok Hwa Kang; Hee Sung Chae; Brice Obiang-Obounou; Young Seob Lee; You Chang Oh; Min San Kim; Dong Won Shin; Jeong Ah Kim; Young Ho Kim; Dong Yeul Kwon

doi:10.1007/s12010-009-8698-5

Antibacterial activity of hylomecon hylomeconoides against methicillin-resistant staphylococcus aureus

Jang Gi Choi
, Ok Hwa Kang
, Hee Sung Chae
, Brice Obiang-Obounou
, Young Seob Lee
, You Chang Oh
, Min San Kim
, Dong Won Shin
, Jeong Ah Kim
, Young Ho Kim
, Dong Yeul Kwon

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH₂Cl₂, EtOAc, and H₂O) were investigated against MRSA. The most active extract (CH₂Cl ₂) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 μg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 μg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.

Original language	English
Pages (from-to)	2467-2474
Number of pages	8
Journal	Applied Biochemistry and Biotechnology
Volume	160
Issue number	8
DOIs	https://doi.org/10.1007/s12010-009-8698-5
State	Published - Apr 2010

Keywords

6-Methoxydihydrosanguinarine
Antibacterial
EtOH extract
Hylomecon hylomeconoides
MRSA

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10.1007/s12010-009-8698-5

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@article{3af501323a704941b187cd89e7c13050,

title = "Antibacterial activity of hylomecon hylomeconoides against methicillin-resistant staphylococcus aureus",

abstract = "Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH2Cl2, EtOAc, and H2O) were investigated against MRSA. The most active extract (CH2Cl 2) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 μg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 μg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.",

keywords = "6-Methoxydihydrosanguinarine, Antibacterial, EtOH extract, Hylomecon hylomeconoides, MRSA",

author = "Choi, \{Jang Gi\} and Kang, \{Ok Hwa\} and Chae, \{Hee Sung\} and Brice Obiang-Obounou and Lee, \{Young Seob\} and Oh, \{You Chang\} and Kim, \{Min San\} and Shin, \{Dong Won\} and Kim, \{Jeong Ah\} and Kim, \{Young Ho\} and Kwon, \{Dong Yeul\}",

year = "2010",

month = apr,

doi = "10.1007/s12010-009-8698-5",

language = "English",

volume = "160",

pages = "2467--2474",

journal = "Applied Biochemistry and Biotechnology",

issn = "0273-2289",

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TY - JOUR

T1 - Antibacterial activity of hylomecon hylomeconoides against methicillin-resistant staphylococcus aureus

AU - Choi, Jang Gi

AU - Kang, Ok Hwa

AU - Chae, Hee Sung

AU - Obiang-Obounou, Brice

AU - Lee, Young Seob

AU - Oh, You Chang

AU - Kim, Min San

AU - Shin, Dong Won

AU - Kim, Jeong Ah

AU - Kim, Young Ho

AU - Kwon, Dong Yeul

PY - 2010/4

Y1 - 2010/4

N2 - Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH2Cl2, EtOAc, and H2O) were investigated against MRSA. The most active extract (CH2Cl 2) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 μg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 μg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.

AB - Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH2Cl2, EtOAc, and H2O) were investigated against MRSA. The most active extract (CH2Cl 2) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 μg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 μg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.

KW - 6-Methoxydihydrosanguinarine

KW - Antibacterial

KW - EtOH extract

KW - Hylomecon hylomeconoides

KW - MRSA

UR - https://www.scopus.com/pages/publications/77949917260

U2 - 10.1007/s12010-009-8698-5

DO - 10.1007/s12010-009-8698-5

M3 - Article

C2 - 19578993

AN - SCOPUS:77949917260

SN - 0273-2289

VL - 160

SP - 2467

EP - 2474

JO - Applied Biochemistry and Biotechnology

JF - Applied Biochemistry and Biotechnology

IS - 8

ER -

Antibacterial activity of hylomecon hylomeconoides against methicillin-resistant staphylococcus aureus

Abstract

Keywords

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