Abstract
We investigated novel antibacterial and synergistic activities of isocryptomerin isolated from Selaginella tamariscina. Isocryptomerin showed potent antibacterial activity against Gram-positive and Gram-negative bacterial strains including clinical isolates of antibiotic-resistant species such as methicillin-resistant Staphylococcus aureus (MRSA). Additionally, we further investigated the synergistic activity of isocryptomerin with a conventional antibiotic against MRSA. The result indicated that isocryptomerin had considerable synergistic activity in combination with cefotaxime. In summary, the present study suggests that isocryptomerin may have potential as a novel therapeutic agent for treatment of infectious diseases by not only human pathogenic bacteria but also multidrug-resistant bacteria.
| Original language | English |
|---|---|
| Pages (from-to) | 204-207 |
| Number of pages | 4 |
| Journal | Journal of Microbiology and Biotechnology |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| State | Published - 28 Feb 2009 |
Keywords
- Antibacterial activity
- Isocryptomerin
- Synergistic activity
