Antibacterial Effect of Berberrubine on the Salmonella typhimurium Type III Secretion System

Won Sik Choi; Tae Hun Lee; Se Jin Son; Yeo Reum Park; Tae Young Lee; Ahsan Javed; Deokyeong Choe; Solomon L. Kim; Sung Uk Kim; Sang Han Lee

doi:10.1177/1934578X231189077

Antibacterial Effect of Berberrubine on the Salmonella typhimurium Type III Secretion System

Won Sik Choi, Tae Hun Lee, Se Jin Son, Yeo Reum Park, Tae Young Lee, Ahsan Javed, Deokyeong Choe, Solomon L. Kim, Sung Uk Kim, Sang Han Lee

Research output: Contribution to journal › Article › peer-review

Abstract

The increasing antimicrobial drug resistance of Salmonella typhimurium has been a major public health problem in many countries. The type III secretion system (TTSS) of S typhimurium is an attractive target for the development of new antibiotics against this bacterium. In this study, we determined whether berberrubine derived from Berberis vulgaris could inhibit TTSS expression in S typhimurium. Berberrubine inhibited TTSS expression at a concentration of 60.9 µM. Additionally, TTSS-related mRNA expression of sipA, sipB, sopA, and sopD was downregulated in the presence of berberrubine. Collectively, we anticipate that berberrubine can be a useful tool to prevent the risks of infections caused by pathogenic bacteria.

Original language	English
Journal	Natural Product Communications
Volume	18
Issue number	9
DOIs	https://doi.org/10.1177/1934578X231189077
State	Published - Sep 2023

Keywords

Berberis vulgaris
berberrubine
infection
Salmonella typhimurium
type III secretion system

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1934578X231189077

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title = "Antibacterial Effect of Berberrubine on the Salmonella typhimurium Type III Secretion System",

abstract = "The increasing antimicrobial drug resistance of Salmonella typhimurium has been a major public health problem in many countries. The type III secretion system (TTSS) of S typhimurium is an attractive target for the development of new antibiotics against this bacterium. In this study, we determined whether berberrubine derived from Berberis vulgaris could inhibit TTSS expression in S typhimurium. Berberrubine inhibited TTSS expression at a concentration of 60.9 µM. Additionally, TTSS-related mRNA expression of sipA, sipB, sopA, and sopD was downregulated in the presence of berberrubine. Collectively, we anticipate that berberrubine can be a useful tool to prevent the risks of infections caused by pathogenic bacteria.",

keywords = "Berberis vulgaris, berberrubine, infection, Salmonella typhimurium, type III secretion system",

author = "Choi, {Won Sik} and Lee, {Tae Hun} and Son, {Se Jin} and Park, {Yeo Reum} and Lee, {Tae Young} and Ahsan Javed and Deokyeong Choe and Kim, {Solomon L.} and Kim, {Sung Uk} and Lee, {Sang Han}",

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doi = "10.1177/1934578X231189077",

language = "English",

volume = "18",

journal = "Natural Product Communications",

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T1 - Antibacterial Effect of Berberrubine on the Salmonella typhimurium Type III Secretion System

AU - Choi, Won Sik

AU - Lee, Tae Hun

AU - Son, Se Jin

AU - Park, Yeo Reum

AU - Lee, Tae Young

AU - Javed, Ahsan

AU - Choe, Deokyeong

AU - Kim, Solomon L.

AU - Kim, Sung Uk

AU - Lee, Sang Han

PY - 2023/9

Y1 - 2023/9

N2 - The increasing antimicrobial drug resistance of Salmonella typhimurium has been a major public health problem in many countries. The type III secretion system (TTSS) of S typhimurium is an attractive target for the development of new antibiotics against this bacterium. In this study, we determined whether berberrubine derived from Berberis vulgaris could inhibit TTSS expression in S typhimurium. Berberrubine inhibited TTSS expression at a concentration of 60.9 µM. Additionally, TTSS-related mRNA expression of sipA, sipB, sopA, and sopD was downregulated in the presence of berberrubine. Collectively, we anticipate that berberrubine can be a useful tool to prevent the risks of infections caused by pathogenic bacteria.

AB - The increasing antimicrobial drug resistance of Salmonella typhimurium has been a major public health problem in many countries. The type III secretion system (TTSS) of S typhimurium is an attractive target for the development of new antibiotics against this bacterium. In this study, we determined whether berberrubine derived from Berberis vulgaris could inhibit TTSS expression in S typhimurium. Berberrubine inhibited TTSS expression at a concentration of 60.9 µM. Additionally, TTSS-related mRNA expression of sipA, sipB, sopA, and sopD was downregulated in the presence of berberrubine. Collectively, we anticipate that berberrubine can be a useful tool to prevent the risks of infections caused by pathogenic bacteria.

KW - Berberis vulgaris

KW - berberrubine

KW - infection

KW - Salmonella typhimurium

KW - type III secretion system

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U2 - 10.1177/1934578X231189077

DO - 10.1177/1934578X231189077

M3 - Article

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SN - 1934-578X

VL - 18

JO - Natural Product Communications

JF - Natural Product Communications

IS - 9

ER -

Antibacterial Effect of Berberrubine on the Salmonella typhimurium Type III Secretion System

Abstract

Keywords

UN SDGs

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