Antibacterial Effect of Berberrubine on the Salmonella typhimurium Type III Secretion System

Won Sik Choi; Tae Hun Lee; Se Jin Son; Yeo Reum Park; Tae Young Lee; Ahsan Javed; Deokyeong Choe; Solomon L. Kim; Sung Uk Kim; Sang Han Lee

doi:10.1177/1934578X231189077

Antibacterial Effect of Berberrubine on the Salmonella typhimurium Type III Secretion System

Won Sik Choi
, Tae Hun Lee
, Se Jin Son
, Yeo Reum Park
, Tae Young Lee
, Ahsan Javed
, Deokyeong Choe
, Solomon L. Kim
, Sung Uk Kim
, Sang Han Lee

Ltd
Center for Infectious Diseases Research
Kyungpook National University
California Northstate University
Korea Research Institute of Bioscience and Biotechnology
Seowon University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The increasing antimicrobial drug resistance of Salmonella typhimurium has been a major public health problem in many countries. The type III secretion system (TTSS) of S typhimurium is an attractive target for the development of new antibiotics against this bacterium. In this study, we determined whether berberrubine derived from Berberis vulgaris could inhibit TTSS expression in S typhimurium. Berberrubine inhibited TTSS expression at a concentration of 60.9 µM. Additionally, TTSS-related mRNA expression of sipA, sipB, sopA, and sopD was downregulated in the presence of berberrubine. Collectively, we anticipate that berberrubine can be a useful tool to prevent the risks of infections caused by pathogenic bacteria.

Original language	English
Journal	Natural Product Communications
Volume	18
Issue number	9
DOIs	https://doi.org/10.1177/1934578X231189077
State	Published - Sep 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Berberis vulgaris
Salmonella typhimurium
berberrubine
infection
type III secretion system

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10.1177/1934578X231189077

Cite this

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title = "Antibacterial Effect of Berberrubine on the Salmonella typhimurium Type III Secretion System",

abstract = "The increasing antimicrobial drug resistance of Salmonella typhimurium has been a major public health problem in many countries. The type III secretion system (TTSS) of S typhimurium is an attractive target for the development of new antibiotics against this bacterium. In this study, we determined whether berberrubine derived from Berberis vulgaris could inhibit TTSS expression in S typhimurium. Berberrubine inhibited TTSS expression at a concentration of 60.9 µM. Additionally, TTSS-related mRNA expression of sipA, sipB, sopA, and sopD was downregulated in the presence of berberrubine. Collectively, we anticipate that berberrubine can be a useful tool to prevent the risks of infections caused by pathogenic bacteria.",

keywords = "Berberis vulgaris, Salmonella typhimurium, berberrubine, infection, type III secretion system",

author = "Choi, \{Won Sik\} and Lee, \{Tae Hun\} and Son, \{Se Jin\} and Park, \{Yeo Reum\} and Lee, \{Tae Young\} and Ahsan Javed and Deokyeong Choe and Kim, \{Solomon L.\} and Kim, \{Sung Uk\} and Lee, \{Sang Han\}",

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year = "2023",

month = sep,

doi = "10.1177/1934578X231189077",

language = "English",

volume = "18",

journal = "Natural Product Communications",

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T1 - Antibacterial Effect of Berberrubine on the Salmonella typhimurium Type III Secretion System

AU - Choi, Won Sik

AU - Lee, Tae Hun

AU - Son, Se Jin

AU - Park, Yeo Reum

AU - Lee, Tae Young

AU - Javed, Ahsan

AU - Choe, Deokyeong

AU - Kim, Solomon L.

AU - Kim, Sung Uk

AU - Lee, Sang Han

PY - 2023/9

Y1 - 2023/9

N2 - The increasing antimicrobial drug resistance of Salmonella typhimurium has been a major public health problem in many countries. The type III secretion system (TTSS) of S typhimurium is an attractive target for the development of new antibiotics against this bacterium. In this study, we determined whether berberrubine derived from Berberis vulgaris could inhibit TTSS expression in S typhimurium. Berberrubine inhibited TTSS expression at a concentration of 60.9 µM. Additionally, TTSS-related mRNA expression of sipA, sipB, sopA, and sopD was downregulated in the presence of berberrubine. Collectively, we anticipate that berberrubine can be a useful tool to prevent the risks of infections caused by pathogenic bacteria.

AB - The increasing antimicrobial drug resistance of Salmonella typhimurium has been a major public health problem in many countries. The type III secretion system (TTSS) of S typhimurium is an attractive target for the development of new antibiotics against this bacterium. In this study, we determined whether berberrubine derived from Berberis vulgaris could inhibit TTSS expression in S typhimurium. Berberrubine inhibited TTSS expression at a concentration of 60.9 µM. Additionally, TTSS-related mRNA expression of sipA, sipB, sopA, and sopD was downregulated in the presence of berberrubine. Collectively, we anticipate that berberrubine can be a useful tool to prevent the risks of infections caused by pathogenic bacteria.

KW - Berberis vulgaris

KW - Salmonella typhimurium

KW - berberrubine

KW - infection

KW - type III secretion system

UR - https://www.scopus.com/pages/publications/85172024955

U2 - 10.1177/1934578X231189077

DO - 10.1177/1934578X231189077

M3 - Article

AN - SCOPUS:85172024955

SN - 1934-578X

VL - 18

JO - Natural Product Communications

JF - Natural Product Communications

IS - 9

ER -

Antibacterial Effect of Berberrubine on the Salmonella typhimurium Type III Secretion System

Abstract

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Keywords

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