Antibacterial Effect of Naringin-containing Soft Contact Lens

Giseop Kwak; Hyeryun Kim; Woo Dong Jang; Geun Chang Ryu; In Suk Kim

doi:10.1002/bkcs.12375

Antibacterial Effect of Naringin-containing Soft Contact Lens

Giseop Kwak, Hyeryun Kim, Woo Dong Jang, Geun Chang Ryu, In Suk Kim

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A naringin-containing soft contact lens (NCSC) was prepared as an antibacterial platform for long-term wearable soft contact lens. The NCSC showed sustained release of naringin for about a period of 1 month without changing the surface morphology. The effluent solution from NCSC exhibited very low cytotoxicity and high antibacterial activities against Pseudomonas aeruginosa and Escherichia coli. In the intraocular eye drop experiments of effluent solution from NCSC, it had no difference with the control group and showed unstimulated status without any cell damage or side effect. The NCSC showed smoother surface with reduced contamination by P. aeruginosa after wearing of 3 consecutive weeks whereas the control soft contact lens showed extremely high contamination, indicating the effective antibacterial effect of NCSC upon extended wearing.

Original language	English
Pages (from-to)	1345-1350
Number of pages	6
Journal	Bulletin of the Korean Chemical Society
Volume	42
Issue number	10
DOIs	https://doi.org/10.1002/bkcs.12375
State	Published - Oct 2021

Keywords

Antibacterial effect
Controlled release
Drug delivery
Naringin
Soft contact lens

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10.1002/bkcs.12375

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title = "Antibacterial Effect of Naringin-containing Soft Contact Lens",

abstract = "A naringin-containing soft contact lens (NCSC) was prepared as an antibacterial platform for long-term wearable soft contact lens. The NCSC showed sustained release of naringin for about a period of 1 month without changing the surface morphology. The effluent solution from NCSC exhibited very low cytotoxicity and high antibacterial activities against Pseudomonas aeruginosa and Escherichia coli. In the intraocular eye drop experiments of effluent solution from NCSC, it had no difference with the control group and showed unstimulated status without any cell damage or side effect. The NCSC showed smoother surface with reduced contamination by P. aeruginosa after wearing of 3 consecutive weeks whereas the control soft contact lens showed extremely high contamination, indicating the effective antibacterial effect of NCSC upon extended wearing.",

keywords = "Antibacterial effect, Controlled release, Drug delivery, Naringin, Soft contact lens",

author = "Giseop Kwak and Hyeryun Kim and Jang, {Woo Dong} and Ryu, {Geun Chang} and Kim, {In Suk}",

note = "Publisher Copyright: {\textcopyright} 2021 Korean Chemical Society and Wiley-VCH GmbH.",

year = "2021",

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doi = "10.1002/bkcs.12375",

language = "English",

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TY - JOUR

T1 - Antibacterial Effect of Naringin-containing Soft Contact Lens

AU - Kwak, Giseop

AU - Kim, Hyeryun

AU - Jang, Woo Dong

AU - Ryu, Geun Chang

AU - Kim, In Suk

PY - 2021/10

Y1 - 2021/10

N2 - A naringin-containing soft contact lens (NCSC) was prepared as an antibacterial platform for long-term wearable soft contact lens. The NCSC showed sustained release of naringin for about a period of 1 month without changing the surface morphology. The effluent solution from NCSC exhibited very low cytotoxicity and high antibacterial activities against Pseudomonas aeruginosa and Escherichia coli. In the intraocular eye drop experiments of effluent solution from NCSC, it had no difference with the control group and showed unstimulated status without any cell damage or side effect. The NCSC showed smoother surface with reduced contamination by P. aeruginosa after wearing of 3 consecutive weeks whereas the control soft contact lens showed extremely high contamination, indicating the effective antibacterial effect of NCSC upon extended wearing.

AB - A naringin-containing soft contact lens (NCSC) was prepared as an antibacterial platform for long-term wearable soft contact lens. The NCSC showed sustained release of naringin for about a period of 1 month without changing the surface morphology. The effluent solution from NCSC exhibited very low cytotoxicity and high antibacterial activities against Pseudomonas aeruginosa and Escherichia coli. In the intraocular eye drop experiments of effluent solution from NCSC, it had no difference with the control group and showed unstimulated status without any cell damage or side effect. The NCSC showed smoother surface with reduced contamination by P. aeruginosa after wearing of 3 consecutive weeks whereas the control soft contact lens showed extremely high contamination, indicating the effective antibacterial effect of NCSC upon extended wearing.

KW - Antibacterial effect

KW - Controlled release

KW - Drug delivery

KW - Naringin

KW - Soft contact lens

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DO - 10.1002/bkcs.12375

M3 - Article

AN - SCOPUS:85111761399

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EP - 1350

JO - Bulletin of the Korean Chemical Society

JF - Bulletin of the Korean Chemical Society

IS - 10

ER -

Antibacterial Effect of Naringin-containing Soft Contact Lens

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