Abstract
Candida albicans is opportunistic fungus which is in normal part of human gut flora also commonly present on the skin and in mucous membranes. It is normally a harmless commensal of human beings. However, when the body environment allows C. albicans to grow out of control, it becomes infectious and causes candidiasis. A variety of antifungal agents have been developed and used to treat candidiasis caused by C. albicans such as azoles, polyenes, pyrimidines, allylamines and echinocandins. The antifungal mechanism of these agent is reported to target the cell membrane, cell wall synthesis, and intracellular macromolecules. Recent researches also showed that some of these agents exert its antifungal activity by inducing apoptosis, which is mediated by intracellular reactive oxygen species generation. Analysis and application of these antifungal mechanisms will be a great remedy for the treatment of C. albicans infection.
| Original language | English |
|---|---|
| Title of host publication | Candida Albicans |
| Subtitle of host publication | Symptoms, Diagnosis and Treatment |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 61-71 |
| Number of pages | 11 |
| ISBN (Electronic) | 9781536155617 |
| ISBN (Print) | 9781536155600 |
| State | Published - 1 Jan 2019 |
Keywords
- antifungal agent
- antifungal mechanism
- apoptosis
- Candida albicans
- fungal infection