Abstract
In order to obtain a synthetic peptide with a more potent antifungal activity than magainin-2 but without hemolytic activity, four hybrid peptides were designed from the sequences of magainin 2 and cecropin A and their antifungal activities against Trichosporon beigelii were investigated. The result showed that analogue 2 and 4 exhibited better antifungal activity against T. beigelii than magainin-2 but no hemolytic activities. The peptides, therefore, could be used as models for the development of potent antifungal peptides.
| Original language | English |
|---|---|
| Pages (from-to) | 49-51 |
| Number of pages | 3 |
| Journal | Journal of Microbiology and Biotechnology |
| Volume | 7 |
| Issue number | 1 |
| State | Published - 1997 |
Keywords
- Antifungal activity
- Hybrid synthetic peptides
- Magainin-2
- Trichosporon beigelit