Antifungal and antiaflatoxigenic effects of a fumigant, ethanedinitrile, on Aspergillus flavus

Hoon Choi; Byung Ho Lee; Young Sun Moon; Kyeongsoon Kim; Hoi Seon Lee; Sung Eun Lee

doi:10.1007/s13765-017-0301-0

Antifungal and antiaflatoxigenic effects of a fumigant, ethanedinitrile, on Aspergillus flavus

Hoon Choi, Byung Ho Lee, Young Sun Moon, Kyeongsoon Kim, Hoi Seon Lee, Sung Eun Lee

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Antifungal effects of ethanedinitrile (EDN) and ethyl formate (EF) on Aspergillus flavus were investigated using radial growth bioassay. A. flavus was inoculated in the center of potato dextrose agar plate and treated with 1, 5, and 10 g/m³ of EDN, or 5, 35, and 70 g/m³ of EF. EDN strongly inhibited fungal growth. At 1 g/m³ of EDN, the fungal growth reduced by 22.2% by the final days of culture. The growth was completely inhibited by EDN at the concentration of 5 g/m³. Antiaflatoxigenic activity of both the fumigants was also assessed. Aflatoxin formation was determined using high-performance liquid chromatography with a fluorescence detector. A. flavus did not produce aflatoxin B₁ and aflatoxin B₂ at EDN concentrations >5 g. EF had no inhibitory effect on A. flavus growth and the formation of aflatoxin. These results suggest that EDN can be an alternative for currently used antifungal agents to control fungal and aflatoxin contamination of stored grains.

Original language	English
Pages (from-to)	473-476
Number of pages	4
Journal	Applied Biological Chemistry
Volume	60
Issue number	5
DOIs	https://doi.org/10.1007/s13765-017-0301-0
State	Published - 1 Oct 2017

Keywords

Aflatoxin B
Aflatoxin B
Aspergillus flavus
Ethanedinitrile
Ethyl formate

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10.1007/s13765-017-0301-0

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title = "Antifungal and antiaflatoxigenic effects of a fumigant, ethanedinitrile, on Aspergillus flavus",

abstract = "Antifungal effects of ethanedinitrile (EDN) and ethyl formate (EF) on Aspergillus flavus were investigated using radial growth bioassay. A. flavus was inoculated in the center of potato dextrose agar plate and treated with 1, 5, and 10 g/m3 of EDN, or 5, 35, and 70 g/m3 of EF. EDN strongly inhibited fungal growth. At 1 g/m3 of EDN, the fungal growth reduced by 22.2% by the final days of culture. The growth was completely inhibited by EDN at the concentration of 5 g/m3. Antiaflatoxigenic activity of both the fumigants was also assessed. Aflatoxin formation was determined using high-performance liquid chromatography with a fluorescence detector. A. flavus did not produce aflatoxin B1 and aflatoxin B2 at EDN concentrations >5 g. EF had no inhibitory effect on A. flavus growth and the formation of aflatoxin. These results suggest that EDN can be an alternative for currently used antifungal agents to control fungal and aflatoxin contamination of stored grains.",

keywords = "Aflatoxin B, Aflatoxin B, Aspergillus flavus, Ethanedinitrile, Ethyl formate",

author = "Hoon Choi and Lee, {Byung Ho} and Moon, {Young Sun} and Kyeongsoon Kim and Lee, {Hoi Seon} and Lee, {Sung Eun}",

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AU - Choi, Hoon

AU - Lee, Byung Ho

AU - Moon, Young Sun

AU - Kim, Kyeongsoon

AU - Lee, Hoi Seon

AU - Lee, Sung Eun

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Antifungal effects of ethanedinitrile (EDN) and ethyl formate (EF) on Aspergillus flavus were investigated using radial growth bioassay. A. flavus was inoculated in the center of potato dextrose agar plate and treated with 1, 5, and 10 g/m3 of EDN, or 5, 35, and 70 g/m3 of EF. EDN strongly inhibited fungal growth. At 1 g/m3 of EDN, the fungal growth reduced by 22.2% by the final days of culture. The growth was completely inhibited by EDN at the concentration of 5 g/m3. Antiaflatoxigenic activity of both the fumigants was also assessed. Aflatoxin formation was determined using high-performance liquid chromatography with a fluorescence detector. A. flavus did not produce aflatoxin B1 and aflatoxin B2 at EDN concentrations >5 g. EF had no inhibitory effect on A. flavus growth and the formation of aflatoxin. These results suggest that EDN can be an alternative for currently used antifungal agents to control fungal and aflatoxin contamination of stored grains.

AB - Antifungal effects of ethanedinitrile (EDN) and ethyl formate (EF) on Aspergillus flavus were investigated using radial growth bioassay. A. flavus was inoculated in the center of potato dextrose agar plate and treated with 1, 5, and 10 g/m3 of EDN, or 5, 35, and 70 g/m3 of EF. EDN strongly inhibited fungal growth. At 1 g/m3 of EDN, the fungal growth reduced by 22.2% by the final days of culture. The growth was completely inhibited by EDN at the concentration of 5 g/m3. Antiaflatoxigenic activity of both the fumigants was also assessed. Aflatoxin formation was determined using high-performance liquid chromatography with a fluorescence detector. A. flavus did not produce aflatoxin B1 and aflatoxin B2 at EDN concentrations >5 g. EF had no inhibitory effect on A. flavus growth and the formation of aflatoxin. These results suggest that EDN can be an alternative for currently used antifungal agents to control fungal and aflatoxin contamination of stored grains.

KW - Aflatoxin B

KW - Aspergillus flavus

KW - Ethanedinitrile

KW - Ethyl formate

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JO - Applied Biological Chemistry

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IS - 5

ER -

Antifungal and antiaflatoxigenic effects of a fumigant, ethanedinitrile, on Aspergillus flavus

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