Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii

Bomi Hwang; Juneyoung Lee; Qing He Liu; Eun Rhan Woo; Dong Gun Lee

doi:10.3390/molecules15053507

Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii

Bomi Hwang, Juneyoung Lee, Qing He Liu, Eun Rhan Woo, Dong Gun Lee

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

In this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii, used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of (+)-pinoresinol, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis using 1,6-diphenyl-1,3,5-hexatriene (DPH) indicated that the (+)-pinoresinol caused damage to the fungal plasma membrane. This result was confirmed by using rhodamine-labeled giant unilamellar vesicle (GUV) experiments. Therefore, the present study indicates that (+)-pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.

Original language	English
Pages (from-to)	3507-3516
Number of pages	10
Journal	Molecules
Volume	15
Issue number	5
DOIs	https://doi.org/10.3390/molecules15053507
State	Published - May 2010

Keywords

(+)-Pinoresinol
Antifungal compound
Lignan
Membrane-active mechanism
Sambucus williamsii HANCE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/molecules15053507

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title = "Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii",

abstract = "In this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii, used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of (+)-pinoresinol, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis using 1,6-diphenyl-1,3,5-hexatriene (DPH) indicated that the (+)-pinoresinol caused damage to the fungal plasma membrane. This result was confirmed by using rhodamine-labeled giant unilamellar vesicle (GUV) experiments. Therefore, the present study indicates that (+)-pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.",

keywords = "(+)-Pinoresinol, Antifungal compound, Lignan, Membrane-active mechanism, Sambucus williamsii HANCE",

author = "Bomi Hwang and Juneyoung Lee and Liu, {Qing He} and Woo, {Eun Rhan} and Lee, {Dong Gun}",

year = "2010",

month = may,

doi = "10.3390/molecules15053507",

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pages = "3507--3516",

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TY - JOUR

T1 - Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii

AU - Hwang, Bomi

AU - Lee, Juneyoung

AU - Liu, Qing He

AU - Woo, Eun Rhan

AU - Lee, Dong Gun

PY - 2010/5

Y1 - 2010/5

N2 - In this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii, used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of (+)-pinoresinol, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis using 1,6-diphenyl-1,3,5-hexatriene (DPH) indicated that the (+)-pinoresinol caused damage to the fungal plasma membrane. This result was confirmed by using rhodamine-labeled giant unilamellar vesicle (GUV) experiments. Therefore, the present study indicates that (+)-pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.

AB - In this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii, used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of (+)-pinoresinol, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis using 1,6-diphenyl-1,3,5-hexatriene (DPH) indicated that the (+)-pinoresinol caused damage to the fungal plasma membrane. This result was confirmed by using rhodamine-labeled giant unilamellar vesicle (GUV) experiments. Therefore, the present study indicates that (+)-pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.

KW - (+)-Pinoresinol

KW - Antifungal compound

KW - Lignan

KW - Membrane-active mechanism

KW - Sambucus williamsii HANCE

UR - http://www.scopus.com/inward/record.url?scp=77952800177&partnerID=8YFLogxK

U2 - 10.3390/molecules15053507

DO - 10.3390/molecules15053507

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AN - SCOPUS:77952800177

SN - 1420-3049

VL - 15

SP - 3507

EP - 3516

JO - Molecules

JF - Molecules

IS - 5

ER -

Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii

Abstract

Keywords

UN SDGs

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