Abstract
Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 μg/ml). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 μg/ml; fluconazole IC80, 10-30 μg/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications.
| Original language | English |
|---|---|
| Pages (from-to) | 1482-1484 |
| Number of pages | 3 |
| Journal | Journal of Microbiology and Biotechnology |
| Volume | 18 |
| Issue number | 8 |
| State | Published - 28 Aug 2008 |
Keywords
- Antifungal effect
- Candida species
- Silver nanoparticles
- Trichophyton mentagrophytes