Antifungal effect with apoptotic mechanism(s) of Styraxjaponoside C

Cana Park; Eun Rhan Woo; Dong Gun Lee

doi:10.1016/j.bbrc.2009.10.131

Antifungal effect with apoptotic mechanism(s) of Styraxjaponoside C

Cana Park, Eun Rhan Woo, Dong Gun Lee

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13 Scopus citations

Abstract

The antifungal effects and mechanisms of Styraxjaponoside C were investigated. Styraxjaponoside C was active against several human pathogens, including Candida albicans. Styraxjaponoside C induced a series of cellular changes characteristic of apoptosis in C. albicans, including increased reactive oxygen species (ROS) production, measured by DHR-123 staining; phosphatidylserine externalization, visualized by Annexin V staining; DNA fragmentation, as seen by TUNEL; and plasma membrane depolarization, observed by DiBAC₄(3) staining. The plasma membrane depolarization is likely to be associated with production of ROS. The current study suggests that Styraxjaponoside C exerts an antifungal effect by promoting apoptosis.

Original language	English
Pages (from-to)	1255-1259
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	390
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2009.10.131
State	Published - 25 Dec 2009

Keywords

Antifungal activity
Apoptosis
Lignans
Styrax japonica S. et Z
Styraxjaponoside C

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10.1016/j.bbrc.2009.10.131

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title = "Antifungal effect with apoptotic mechanism(s) of Styraxjaponoside C",

abstract = "The antifungal effects and mechanisms of Styraxjaponoside C were investigated. Styraxjaponoside C was active against several human pathogens, including Candida albicans. Styraxjaponoside C induced a series of cellular changes characteristic of apoptosis in C. albicans, including increased reactive oxygen species (ROS) production, measured by DHR-123 staining; phosphatidylserine externalization, visualized by Annexin V staining; DNA fragmentation, as seen by TUNEL; and plasma membrane depolarization, observed by DiBAC4(3) staining. The plasma membrane depolarization is likely to be associated with production of ROS. The current study suggests that Styraxjaponoside C exerts an antifungal effect by promoting apoptosis.",

keywords = "Antifungal activity, Apoptosis, Lignans, Styrax japonica S. et Z, Styraxjaponoside C",

author = "Cana Park and Woo, \{Eun Rhan\} and Lee, \{Dong Gun\}",

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T1 - Antifungal effect with apoptotic mechanism(s) of Styraxjaponoside C

AU - Park, Cana

AU - Woo, Eun Rhan

AU - Lee, Dong Gun

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N2 - The antifungal effects and mechanisms of Styraxjaponoside C were investigated. Styraxjaponoside C was active against several human pathogens, including Candida albicans. Styraxjaponoside C induced a series of cellular changes characteristic of apoptosis in C. albicans, including increased reactive oxygen species (ROS) production, measured by DHR-123 staining; phosphatidylserine externalization, visualized by Annexin V staining; DNA fragmentation, as seen by TUNEL; and plasma membrane depolarization, observed by DiBAC4(3) staining. The plasma membrane depolarization is likely to be associated with production of ROS. The current study suggests that Styraxjaponoside C exerts an antifungal effect by promoting apoptosis.

AB - The antifungal effects and mechanisms of Styraxjaponoside C were investigated. Styraxjaponoside C was active against several human pathogens, including Candida albicans. Styraxjaponoside C induced a series of cellular changes characteristic of apoptosis in C. albicans, including increased reactive oxygen species (ROS) production, measured by DHR-123 staining; phosphatidylserine externalization, visualized by Annexin V staining; DNA fragmentation, as seen by TUNEL; and plasma membrane depolarization, observed by DiBAC4(3) staining. The plasma membrane depolarization is likely to be associated with production of ROS. The current study suggests that Styraxjaponoside C exerts an antifungal effect by promoting apoptosis.

KW - Antifungal activity

KW - Apoptosis

KW - Lignans

KW - Styrax japonica S. et Z

KW - Styraxjaponoside C

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M3 - Article

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SN - 0006-291X

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SP - 1255

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Antifungal effect with apoptotic mechanism(s) of Styraxjaponoside C

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Keywords

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