TY - JOUR
T1 - Antihypertensive effects of Korean wild simulated ginseng (Sanyangsam) extracts in spontaneously hypertensive rats
AU - Moon, Jae Nam
AU - Kim, Jong Kuk
AU - Lee, Seul
AU - Kwon, Joong Ho
N1 - Publisher Copyright:
© 2019, The Korean Society of Food Science and Technology.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Ginseng possesses a wide spectrum of medicinal effects and has widely been used in traditional medicine for thousands of years. In this study, the antihypertensive effect of Korean wild simulated ginseng in spontaneously hypertensive rats was investigated. Three groups of hypertensive rats—a group without wild simulated ginseng treatment; another group treated with 100 mg of wild simulated ginseng extract/kg of body weight; and the other group treated with 200 mg of wild simulated ginseng extract/kg of body weight were tested over 8 weeks. The two wild simulated ginseng-treated groups showed significantly (p < 0.05) reduced systolic blood pressure at 4 and 6 weeks of wild simulated ginseng treatment. However, the wild simulated ginseng treatment did not adversely affect the food intake, serum electrolytes, osmolality, heart weight, heart rate, and the cross-section of the aorta as well as enzyme activities. The results suggested that Korean wild simulated ginseng is effectively used for reducing high systolic blood pressure in hypertensive patients without causing adverse health effects.
AB - Ginseng possesses a wide spectrum of medicinal effects and has widely been used in traditional medicine for thousands of years. In this study, the antihypertensive effect of Korean wild simulated ginseng in spontaneously hypertensive rats was investigated. Three groups of hypertensive rats—a group without wild simulated ginseng treatment; another group treated with 100 mg of wild simulated ginseng extract/kg of body weight; and the other group treated with 200 mg of wild simulated ginseng extract/kg of body weight were tested over 8 weeks. The two wild simulated ginseng-treated groups showed significantly (p < 0.05) reduced systolic blood pressure at 4 and 6 weeks of wild simulated ginseng treatment. However, the wild simulated ginseng treatment did not adversely affect the food intake, serum electrolytes, osmolality, heart weight, heart rate, and the cross-section of the aorta as well as enzyme activities. The results suggested that Korean wild simulated ginseng is effectively used for reducing high systolic blood pressure in hypertensive patients without causing adverse health effects.
KW - Antihypertensive effect
KW - Korean wild simulated ginseng
KW - Spontaneously hypertensive rat
KW - Systolic blood pressure
UR - http://www.scopus.com/inward/record.url?scp=85072025956&partnerID=8YFLogxK
U2 - 10.1007/s10068-019-00617-5
DO - 10.1007/s10068-019-00617-5
M3 - Article
AN - SCOPUS:85072025956
SN - 1226-7708
VL - 28
SP - 1563
EP - 1569
JO - Food Science and Biotechnology
JF - Food Science and Biotechnology
IS - 5
ER -