Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae)

Sung Eun Lee; Mi Ran Kim; Jeong Han Kim; Gary R. Takeoka; Tae Wan Kim; Byeoung Soo Park

doi:10.1016/j.phymed.2007.08.001

Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae)

Sung Eun Lee
, Mi Ran Kim
, Jeong Han Kim
, Gary R. Takeoka
, Tae Wan Kim
, Byeoung Soo Park

School of Applied Bioscience

Seoul National University
United States Department of Agriculture
Hankyong National University

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Antimalarial activity of anthothecol, a limonoid of Khaya anthotheca (Meliaceae) against Plasmodium falciparum was tested using a [³H]-hypoxanthine and 48 h culture assay in vitro. Anthotechol showed potent antimalarial activity against malaria parasites with IC₅₀ values of 1.4 and 0.17 μM using two different assays. Also, gedunin had antimalarial activity with IC₅₀ values of 3.1 and 0.14 μM. However, the citrus limonoids, limonin and obacunone did not show any antimalarial activity. The antimalarial activities were compared with the three currently used antimalarial medicines quinine, chloroquinine and artemisinin.

Original language	English
Pages (from-to)	533-535
Number of pages	3
Journal	Phytomedicine
Volume	15
Issue number	6-7
DOIs	https://doi.org/10.1016/j.phymed.2007.08.001
State	Published - 20 Jun 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anthothecol
Antimalarial activity
Gedunin
Khaya anthotheca

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10.1016/j.phymed.2007.08.001

Cite this

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title = "Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae)",

abstract = "Antimalarial activity of anthothecol, a limonoid of Khaya anthotheca (Meliaceae) against Plasmodium falciparum was tested using a [3H]-hypoxanthine and 48 h culture assay in vitro. Anthotechol showed potent antimalarial activity against malaria parasites with IC50 values of 1.4 and 0.17 μM using two different assays. Also, gedunin had antimalarial activity with IC50 values of 3.1 and 0.14 μM. However, the citrus limonoids, limonin and obacunone did not show any antimalarial activity. The antimalarial activities were compared with the three currently used antimalarial medicines quinine, chloroquinine and artemisinin.",

keywords = "Anthothecol, Antimalarial activity, Gedunin, Khaya anthotheca",

author = "Lee, \{Sung Eun\} and Kim, \{Mi Ran\} and Kim, \{Jeong Han\} and Takeoka, \{Gary R.\} and Kim, \{Tae Wan\} and Park, \{Byeoung Soo\}",

year = "2008",

month = jun,

day = "20",

doi = "10.1016/j.phymed.2007.08.001",

language = "English",

volume = "15",

pages = "533--535",

journal = "Phytomedicine",

issn = "0944-7113",

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number = "6-7",

}

TY - JOUR

T1 - Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae)

AU - Lee, Sung Eun

AU - Kim, Mi Ran

AU - Kim, Jeong Han

AU - Takeoka, Gary R.

AU - Kim, Tae Wan

AU - Park, Byeoung Soo

PY - 2008/6/20

Y1 - 2008/6/20

N2 - Antimalarial activity of anthothecol, a limonoid of Khaya anthotheca (Meliaceae) against Plasmodium falciparum was tested using a [3H]-hypoxanthine and 48 h culture assay in vitro. Anthotechol showed potent antimalarial activity against malaria parasites with IC50 values of 1.4 and 0.17 μM using two different assays. Also, gedunin had antimalarial activity with IC50 values of 3.1 and 0.14 μM. However, the citrus limonoids, limonin and obacunone did not show any antimalarial activity. The antimalarial activities were compared with the three currently used antimalarial medicines quinine, chloroquinine and artemisinin.

AB - Antimalarial activity of anthothecol, a limonoid of Khaya anthotheca (Meliaceae) against Plasmodium falciparum was tested using a [3H]-hypoxanthine and 48 h culture assay in vitro. Anthotechol showed potent antimalarial activity against malaria parasites with IC50 values of 1.4 and 0.17 μM using two different assays. Also, gedunin had antimalarial activity with IC50 values of 3.1 and 0.14 μM. However, the citrus limonoids, limonin and obacunone did not show any antimalarial activity. The antimalarial activities were compared with the three currently used antimalarial medicines quinine, chloroquinine and artemisinin.

KW - Anthothecol

KW - Antimalarial activity

KW - Gedunin

KW - Khaya anthotheca

UR - https://www.scopus.com/pages/publications/44649200547

U2 - 10.1016/j.phymed.2007.08.001

DO - 10.1016/j.phymed.2007.08.001

M3 - Article

C2 - 17913482

AN - SCOPUS:44649200547

SN - 0944-7113

VL - 15

SP - 533

EP - 535

JO - Phytomedicine

JF - Phytomedicine

IS - 6-7

ER -

Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae)

Abstract

UN SDGs

Keywords

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