Antimicrobial activity of DW286 against Streptococcus pneumoniae

Hee Soo Park; Sung Ji Jung; Dong Rack Choi; Jin Hwan Kwak

doi:10.1016/j.ijantimicag.2010.04.007

Antimicrobial activity of DW286 against Streptococcus pneumoniae

Hee Soo Park, Sung Ji Jung, Dong Rack Choi, Jin Hwan Kwak

School of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

DW286 is a novel broad-spectrum fluoroquinolone with excellent antipneumococcal activity. The in vitro activity of DW286 was evaluated against quinolone-susceptible and -resistant Streptococcus pneumoniae and was compared with the activities of reference compounds. Among the tested agents, DW286 showed the most potent antibacterial activity against 94 quinolone-susceptible strains [minimum inhibitory concentration (MIC) 0.008-0.03mg/L]. Against 23 quinolone-resistant S. pneumoniae with known resistance mechanisms, DW286 also had the lowest MICs of all the tested quinolones [MIC at which 90% of isolates were inhibited (MIC₉₀)=0.5mg/L], followed by ciprofloxacin, sparfloxacin, moxifloxacin and gemifloxacin. The in vivo activity of DW286 against penicillin-susceptible and -resistant S. pneumoniae was more effective than that of gemifloxacin.

Original language	English
Pages (from-to)	230-233
Number of pages	4
Journal	International Journal of Antimicrobial Agents
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/j.ijantimicag.2010.04.007
State	Published - Sep 2010

Keywords

DW286
Fluoroquinolone
Quinolone resistance-determining regions
Streptococcus pneumoniae

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijantimicag.2010.04.007

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title = "Antimicrobial activity of DW286 against Streptococcus pneumoniae",

abstract = "DW286 is a novel broad-spectrum fluoroquinolone with excellent antipneumococcal activity. The in vitro activity of DW286 was evaluated against quinolone-susceptible and -resistant Streptococcus pneumoniae and was compared with the activities of reference compounds. Among the tested agents, DW286 showed the most potent antibacterial activity against 94 quinolone-susceptible strains [minimum inhibitory concentration (MIC) 0.008-0.03mg/L]. Against 23 quinolone-resistant S. pneumoniae with known resistance mechanisms, DW286 also had the lowest MICs of all the tested quinolones [MIC at which 90\% of isolates were inhibited (MIC90)=0.5mg/L], followed by ciprofloxacin, sparfloxacin, moxifloxacin and gemifloxacin. The in vivo activity of DW286 against penicillin-susceptible and -resistant S. pneumoniae was more effective than that of gemifloxacin.",

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AU - Jung, Sung Ji

AU - Choi, Dong Rack

AU - Kwak, Jin Hwan

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Y1 - 2010/9

N2 - DW286 is a novel broad-spectrum fluoroquinolone with excellent antipneumococcal activity. The in vitro activity of DW286 was evaluated against quinolone-susceptible and -resistant Streptococcus pneumoniae and was compared with the activities of reference compounds. Among the tested agents, DW286 showed the most potent antibacterial activity against 94 quinolone-susceptible strains [minimum inhibitory concentration (MIC) 0.008-0.03mg/L]. Against 23 quinolone-resistant S. pneumoniae with known resistance mechanisms, DW286 also had the lowest MICs of all the tested quinolones [MIC at which 90% of isolates were inhibited (MIC90)=0.5mg/L], followed by ciprofloxacin, sparfloxacin, moxifloxacin and gemifloxacin. The in vivo activity of DW286 against penicillin-susceptible and -resistant S. pneumoniae was more effective than that of gemifloxacin.

AB - DW286 is a novel broad-spectrum fluoroquinolone with excellent antipneumococcal activity. The in vitro activity of DW286 was evaluated against quinolone-susceptible and -resistant Streptococcus pneumoniae and was compared with the activities of reference compounds. Among the tested agents, DW286 showed the most potent antibacterial activity against 94 quinolone-susceptible strains [minimum inhibitory concentration (MIC) 0.008-0.03mg/L]. Against 23 quinolone-resistant S. pneumoniae with known resistance mechanisms, DW286 also had the lowest MICs of all the tested quinolones [MIC at which 90% of isolates were inhibited (MIC90)=0.5mg/L], followed by ciprofloxacin, sparfloxacin, moxifloxacin and gemifloxacin. The in vivo activity of DW286 against penicillin-susceptible and -resistant S. pneumoniae was more effective than that of gemifloxacin.

KW - DW286

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KW - Quinolone resistance-determining regions

KW - Streptococcus pneumoniae

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ER -

Antimicrobial activity of DW286 against Streptococcus pneumoniae

Abstract

Keywords

UN SDGs

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