Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra

Hyung Keun Kim; Yoonkyung Park; Hee Nam Kim; Bo Hwa Choi; Hye Gwang Jeong; Dong Gun Lee; Kyung Soo Hahm

doi:10.1023/A:1020900124997

Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra

Hyung Keun Kim, Yoonkyung Park, Hee Nam Kim, Bo Hwa Choi, Hye Gwang Jeong, Dong Gun Lee, Kyung Soo Hahm

Chosun University

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

β-Glycyrrhetinic acid isolated from Glycyrrhiza glabra had an antibacterial activity of 7.6 and 12.5 μg ml^-1 against Bacillus subtilis and Staphylococcus epidermidis without causing hemolysis of human erythrocytes, whereas it was not inhibitory against Escherichia coli, Proteus vulgaris and various fungi. Confocal microscopy showed that β-glycyrrhetinic acid was located within the bacteria but had not caused membrane disruption. It then inhibited synthesis of DNA, RNA and protein.

Original language	English
Pages (from-to)	1899-1902
Number of pages	4
Journal	Biotechnology Letters
Volume	24
Issue number	22
DOIs	https://doi.org/10.1023/A:1020900124997
State	Published - Nov 2002

Keywords

Confocal microscopy
Licorice
Macromolecule inhibition

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title = "Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra",

abstract = "β-Glycyrrhetinic acid isolated from Glycyrrhiza glabra had an antibacterial activity of 7.6 and 12.5 μg ml-1 against Bacillus subtilis and Staphylococcus epidermidis without causing hemolysis of human erythrocytes, whereas it was not inhibitory against Escherichia coli, Proteus vulgaris and various fungi. Confocal microscopy showed that β-glycyrrhetinic acid was located within the bacteria but had not caused membrane disruption. It then inhibited synthesis of DNA, RNA and protein.",

keywords = "Confocal microscopy, Licorice, Macromolecule inhibition",

author = "Kim, {Hyung Keun} and Yoonkyung Park and Kim, {Hee Nam} and Choi, {Bo Hwa} and Jeong, {Hye Gwang} and Lee, {Dong Gun} and Hahm, {Kyung Soo}",

year = "2002",

month = nov,

doi = "10.1023/A:1020900124997",

language = "English",

volume = "24",

pages = "1899--1902",

journal = "Biotechnology Letters",

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T1 - Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra

AU - Kim, Hyung Keun

AU - Park, Yoonkyung

AU - Kim, Hee Nam

AU - Choi, Bo Hwa

AU - Jeong, Hye Gwang

AU - Lee, Dong Gun

AU - Hahm, Kyung Soo

PY - 2002/11

Y1 - 2002/11

N2 - β-Glycyrrhetinic acid isolated from Glycyrrhiza glabra had an antibacterial activity of 7.6 and 12.5 μg ml-1 against Bacillus subtilis and Staphylococcus epidermidis without causing hemolysis of human erythrocytes, whereas it was not inhibitory against Escherichia coli, Proteus vulgaris and various fungi. Confocal microscopy showed that β-glycyrrhetinic acid was located within the bacteria but had not caused membrane disruption. It then inhibited synthesis of DNA, RNA and protein.

AB - β-Glycyrrhetinic acid isolated from Glycyrrhiza glabra had an antibacterial activity of 7.6 and 12.5 μg ml-1 against Bacillus subtilis and Staphylococcus epidermidis without causing hemolysis of human erythrocytes, whereas it was not inhibitory against Escherichia coli, Proteus vulgaris and various fungi. Confocal microscopy showed that β-glycyrrhetinic acid was located within the bacteria but had not caused membrane disruption. It then inhibited synthesis of DNA, RNA and protein.

KW - Confocal microscopy

KW - Licorice

KW - Macromolecule inhibition

UR - http://www.scopus.com/inward/record.url?scp=0036858999&partnerID=8YFLogxK

U2 - 10.1023/A:1020900124997

DO - 10.1023/A:1020900124997

M3 - Article

AN - SCOPUS:0036858999

SN - 0141-5492

VL - 24

SP - 1899

EP - 1902

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 22

ER -

Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra

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Keywords

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