Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra

Hyung Keun Kim; Yoonkyung Park; Hee Nam Kim; Bo Hwa Choi; Hye Gwang Jeong; Dong Gun Lee; Kyung Soo Hahm

doi:10.1023/A:1020900124997

Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra

Hyung Keun Kim
, Yoonkyung Park
, Hee Nam Kim
, Bo Hwa Choi
, Hye Gwang Jeong
, Dong Gun Lee
, Kyung Soo Hahm

Chosun University

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

β-Glycyrrhetinic acid isolated from Glycyrrhiza glabra had an antibacterial activity of 7.6 and 12.5 μg ml^-1 against Bacillus subtilis and Staphylococcus epidermidis without causing hemolysis of human erythrocytes, whereas it was not inhibitory against Escherichia coli, Proteus vulgaris and various fungi. Confocal microscopy showed that β-glycyrrhetinic acid was located within the bacteria but had not caused membrane disruption. It then inhibited synthesis of DNA, RNA and protein.

Original language	English
Pages (from-to)	1899-1902
Number of pages	4
Journal	Biotechnology Letters
Volume	24
Issue number	22
DOIs	https://doi.org/10.1023/A:1020900124997
State	Published - Nov 2002

Keywords

Confocal microscopy
Licorice
Macromolecule inhibition

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title = "Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra",

abstract = "β-Glycyrrhetinic acid isolated from Glycyrrhiza glabra had an antibacterial activity of 7.6 and 12.5 μg ml-1 against Bacillus subtilis and Staphylococcus epidermidis without causing hemolysis of human erythrocytes, whereas it was not inhibitory against Escherichia coli, Proteus vulgaris and various fungi. Confocal microscopy showed that β-glycyrrhetinic acid was located within the bacteria but had not caused membrane disruption. It then inhibited synthesis of DNA, RNA and protein.",

keywords = "Confocal microscopy, Licorice, Macromolecule inhibition",

author = "Kim, \{Hyung Keun\} and Yoonkyung Park and Kim, \{Hee Nam\} and Choi, \{Bo Hwa\} and Jeong, \{Hye Gwang\} and Lee, \{Dong Gun\} and Hahm, \{Kyung Soo\}",

year = "2002",

month = nov,

doi = "10.1023/A:1020900124997",

language = "English",

volume = "24",

pages = "1899--1902",

journal = "Biotechnology Letters",

issn = "0141-5492",

publisher = "Springer Science and Business Media B.V.",

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TY - JOUR

T1 - Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra

AU - Kim, Hyung Keun

AU - Park, Yoonkyung

AU - Kim, Hee Nam

AU - Choi, Bo Hwa

AU - Jeong, Hye Gwang

AU - Lee, Dong Gun

AU - Hahm, Kyung Soo

PY - 2002/11

Y1 - 2002/11

N2 - β-Glycyrrhetinic acid isolated from Glycyrrhiza glabra had an antibacterial activity of 7.6 and 12.5 μg ml-1 against Bacillus subtilis and Staphylococcus epidermidis without causing hemolysis of human erythrocytes, whereas it was not inhibitory against Escherichia coli, Proteus vulgaris and various fungi. Confocal microscopy showed that β-glycyrrhetinic acid was located within the bacteria but had not caused membrane disruption. It then inhibited synthesis of DNA, RNA and protein.

AB - β-Glycyrrhetinic acid isolated from Glycyrrhiza glabra had an antibacterial activity of 7.6 and 12.5 μg ml-1 against Bacillus subtilis and Staphylococcus epidermidis without causing hemolysis of human erythrocytes, whereas it was not inhibitory against Escherichia coli, Proteus vulgaris and various fungi. Confocal microscopy showed that β-glycyrrhetinic acid was located within the bacteria but had not caused membrane disruption. It then inhibited synthesis of DNA, RNA and protein.

KW - Confocal microscopy

KW - Licorice

KW - Macromolecule inhibition

UR - https://www.scopus.com/pages/publications/0036858999

U2 - 10.1023/A:1020900124997

DO - 10.1023/A:1020900124997

M3 - Article

AN - SCOPUS:0036858999

SN - 0141-5492

VL - 24

SP - 1899

EP - 1902

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 22

ER -

Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra

Abstract

Keywords

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