TY - JOUR
T1 - Antimicrobial peptides (AMPs) with dual mechanisms
T2 - Membrane disruption and apoptosis
AU - Lee, Juneyoung
AU - Lee, Dong Gun
N1 - Publisher Copyright:
© 2015 by The Korean Society for Microbiology and Biotechnology.
PY - 2014/12/24
Y1 - 2014/12/24
N2 - Antimicrobial peptides (AMPs) are one of the critical components in host innate immune responses to imbalanced and invading microbial pathogens. Although the antimicrobial activity and mechanism of action have been thoroughly investigated for decades, the exact biological properties of AMPs are still elusive. Most AMPs generally exert the antimicrobial effect by targeting the microbial membrane, such as barrel stave, toroidal, and carpet mechanisms. Thus, the mode of action in model membranes and the discrimination of AMPs to discrepant lipid compositions between mammalian cells and microbial pathogens (cell selectivity) have been studied intensively. However, the latest reports suggest that not only AMPs recently isolated but also well-known membrane-disruptive AMPs play a role in intracellular killing, such as apoptosis induction. In this mini-review, we will review some representative AMPs and their antimicrobial mechanisms and provide new insights into the dual mechanism of AMPs.
AB - Antimicrobial peptides (AMPs) are one of the critical components in host innate immune responses to imbalanced and invading microbial pathogens. Although the antimicrobial activity and mechanism of action have been thoroughly investigated for decades, the exact biological properties of AMPs are still elusive. Most AMPs generally exert the antimicrobial effect by targeting the microbial membrane, such as barrel stave, toroidal, and carpet mechanisms. Thus, the mode of action in model membranes and the discrimination of AMPs to discrepant lipid compositions between mammalian cells and microbial pathogens (cell selectivity) have been studied intensively. However, the latest reports suggest that not only AMPs recently isolated but also well-known membrane-disruptive AMPs play a role in intracellular killing, such as apoptosis induction. In this mini-review, we will review some representative AMPs and their antimicrobial mechanisms and provide new insights into the dual mechanism of AMPs.
KW - Antimicrobial peptide
KW - Apoptosis induction
KW - Membrane-active action
UR - http://www.scopus.com/inward/record.url?scp=84934887929&partnerID=8YFLogxK
U2 - 10.4014/jmb.1411.11058
DO - 10.4014/jmb.1411.11058
M3 - Article
C2 - 25537721
AN - SCOPUS:84934887929
SN - 1017-7825
VL - 25
SP - 759
EP - 764
JO - Journal of Microbiology and Biotechnology
JF - Journal of Microbiology and Biotechnology
IS - 6
ER -