TY - JOUR
T1 - Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases
AU - Truong, Van Long
AU - Jeong, Woo Sik
N1 - Publisher Copyright:
© 2022
PY - 2022/5
Y1 - 2022/5
N2 - Polyphenols, including phenolic acids, flavonoids, and procyanidins, are abundant in food and beverage derived from plants. Tea (Camellia sinensis) is particularly rich in polyphenols (e.g., catechins, theaflavins, thearubigins, gallic acid, and flavonols), which are thought to contribute to the health benefits of tea. High intake of tea polyphenols has been described to prevent and/or attenuate a variety of chronic pathological conditions like cardiovascular diseases, neurodegenerative diseases, diabetes, and cancer. This review focuses on established antioxidant and anti-inflammatory properties of tea polyphenols and underlying mechanisms of their involvement in inflammatory bowel diseases (IBD). Tea polyphenols act as efficient antioxidants by inducing an endogenous antioxidant defense system and maintaining intracellular redox homeostasis. Tea polyphenols also regulate signaling pathways such as nuclear factor-κB, activator protein 1, signal transducer and activator of transcriptions, and nuclear factor E2-related factor 2, which are associated with IBD development. Accumulating pieces of evidence have indicated that tea polyphenols enhance epithelial barrier function and improve gut microbial dysbiosis, contributing to the management of inflammatory colitis. Therefore, this study suggests that supplementation of tea polyphenols could prevent inflammatory conditions and improve the outcome of patients with IBD.
AB - Polyphenols, including phenolic acids, flavonoids, and procyanidins, are abundant in food and beverage derived from plants. Tea (Camellia sinensis) is particularly rich in polyphenols (e.g., catechins, theaflavins, thearubigins, gallic acid, and flavonols), which are thought to contribute to the health benefits of tea. High intake of tea polyphenols has been described to prevent and/or attenuate a variety of chronic pathological conditions like cardiovascular diseases, neurodegenerative diseases, diabetes, and cancer. This review focuses on established antioxidant and anti-inflammatory properties of tea polyphenols and underlying mechanisms of their involvement in inflammatory bowel diseases (IBD). Tea polyphenols act as efficient antioxidants by inducing an endogenous antioxidant defense system and maintaining intracellular redox homeostasis. Tea polyphenols also regulate signaling pathways such as nuclear factor-κB, activator protein 1, signal transducer and activator of transcriptions, and nuclear factor E2-related factor 2, which are associated with IBD development. Accumulating pieces of evidence have indicated that tea polyphenols enhance epithelial barrier function and improve gut microbial dysbiosis, contributing to the management of inflammatory colitis. Therefore, this study suggests that supplementation of tea polyphenols could prevent inflammatory conditions and improve the outcome of patients with IBD.
KW - Anti-inflammation
KW - Antioxidant
KW - Epithelial barrier function
KW - Gut microbiota
KW - Inflammatory bowel diseases
KW - Tea polyphenols
UR - http://www.scopus.com/inward/record.url?scp=85124030656&partnerID=8YFLogxK
U2 - 10.1016/j.fshw.2021.12.008
DO - 10.1016/j.fshw.2021.12.008
M3 - Review article
AN - SCOPUS:85124030656
SN - 2213-4530
VL - 11
SP - 502
EP - 511
JO - Food Science and Human Wellness
JF - Food Science and Human Wellness
IS - 3
ER -